©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2024; 30(22): 2923-2926
Published online Jun 14, 2024. doi: 10.3748/wjg.v30.i22.2923
Published online Jun 14, 2024. doi: 10.3748/wjg.v30.i22.2923
Interaction between inflammatory bowel disease, physical activity, and myokines: Assessment of serum irisin levels
Marwan SM Al-Nimer, Department of Therapeutics and Clinical Pharmacology, College of Medicine, University of Diyala, Baqubah 32001, Iraq
Author contributions: Al-Nimer MS contributed to writing and editing of the manuscript; Al-Nimer MS fully contributed the Letter to the Editor.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Marwan SM Al-Nimer, MBChB, MD, PhD, Professor Emerita, Department of Therapeutics and Clinical Pharmacology, College of Medicine, University of Diyala, University Street, Baqubah 32001, Iraq. marwanalnimer@yahoo.com
Received: March 13, 2024
Revised: April 30, 2024
Accepted: May 20, 2024
Published online: June 14, 2024
Processing time: 84 Days and 22 Hours
Revised: April 30, 2024
Accepted: May 20, 2024
Published online: June 14, 2024
Processing time: 84 Days and 22 Hours
Core Tip
Core Tip: Irisin is a sports hormone secreted with muscle contraction and serves as an anti-inflammatory biomarker as well as attenuating the intestinal microbiota diversity. Low serum levels of irisin were observed in patients with ulcerative colitis, which can be increased with physical activity. Physical activity is useful in patients presented with extra-intestinal manifestations of inflammatory bowel disease (IBD). Exogenous irisin may overcome the barriers of physical activity in IBD, producing beneficial anti-inflammatory effects and attenuating the microbiota diversity.