Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2024; 30(20): 2689-2708
Published online May 28, 2024. doi: 10.3748/wjg.v30.i20.2689
Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis
Lian-Meng Huang, Ming-Jin Zhang
Lian-Meng Huang, Ming-Jin Zhang, Department of General Surgery, The 901st Hospital of PLA, Hefei 230031, Anhui Province, China
Author contributions: Huang LM contributed to conceptualization, writing original draft; Huang LM and Zhang MJ contributed to data curation, formal analysis, writing - review and editing.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The 901st Hospital of PLA (No. 202311006). The written consent from each participant has been acquired.
Institutional animal care and use committee statement: All animal experiments were approved by the Animal Ethics Committee of Beijing Viewsolid Biotechnology Co. LTD (No. VS2126A00168).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data that support the findings of this study are available from the corresponding author at zhangmingjin2001@163.com.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Jin Zhang, MD, Professor, Department of General Surgery, The 901st Hospital of PLA, No. 424 Changjiang West Road, Shushan District, Hefei 230031, Anhui Province, China. zhangmingjin2001@163.com
Received: December 15, 2023
Revised: February 28, 2024
Accepted: April 19, 2024
Published online: May 28, 2024
Processing time: 164 Days and 6.5 Hours
Core Tip

Core Tip:KIF26B could promote cancer-associated fibroblast activation, mediating macrophage M2 polarization and affecting the occurrence, lung metastasis, and abdominal metastasis of gastric cancer (GC). This study provides useful insights for exploring new mechanisms of GC and suppressing its progression.