Zhou AW, Jin J, Liu Y. Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives. World J Gastroenterol 2024; 30(13): 1791-1800 [PMID: 38659486 DOI: 10.3748/wjg.v30.i13.1791]
Corresponding Author of This Article
Yuan Liu, MD, Assistant Professor, Department of Liver Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai 200127, China. liuyuanbird@163.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 7, 2024; 30(13): 1791-1800 Published online Apr 7, 2024. doi: 10.3748/wjg.v30.i13.1791
Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives
Ai-Wei Zhou, Jing Jin, Yuan Liu
Ai-Wei Zhou, Yuan Liu, Department of Liver Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Jing Jin, Department of Nursing, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Yuan Liu, Department of Liver Transplantation, Shanghai Immune Therapy Institute, Shanghai 200127, China
Co-first authors: Ai-Wei Zhou and Jing Jin.
Author contributions: Zhou AW and Jin J collected the literature, wrote the initial manuscript, conceptualized the table and figure and contributed equally to this work; Yuan L conceptualized the structure of the text, critically revised the manuscript and read and approved the final version of the manuscript.
Supported bythe National Natural Science Foundation of China, No. 82000586 and No. 82241221; and Shanghai Immune Therapy Institute.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan Liu, MD, Assistant Professor, Department of Liver Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai 200127, China. liuyuanbird@163.com
Received: December 30, 2023 Peer-review started: December 30, 2023 First decision: January 16, 2024 Revised: February 3, 2024 Accepted: March 14, 2024 Article in press: March 14, 2024 Published online: April 7, 2024 Processing time: 94 Days and 17.4 Hours
Core Tip
Core Tip: Immune tolerance after liver transplantation could significantly reduce the long-term side-effects of immunosuppressants. Compared with operational and spontaneous tolerance, induced tolerance by cellular therapy could reduce immunosuppressant dosage at early stage after transplantation. Regulatory immune cells could suppress the inflammatory response, which are widely explored in preclinical and clinical trials. So far, regulatory CD4+ T cells, mesenchymal stromal cells and regulatory dendritic cells are mostly studied. However, even the safety and tolerability of cellular therapy in transplantation recipients have been validated, the overall efficacy of tolerance induction is unsatisfactory. Detailed exploration is required in the future.
