Double role of depression in gastric cancer: As a causative factor and as consequence

Core Tip

Core Tip: Gastric cancer (GC), a prevalent malignancy in the digestive system, poses a dual challenge with both physical and psychological implications. While standard treatments like gastrectomy impact patients' quality of life, the psychological burden, including anxiety and depression, cannot be overlooked. Depression, reaching prevalence rates of 57%, significantly influences cancer outcomes, affecting mental well-being, treatment adherence, and overall quality of life. Chronic stress and neurotransmitter dysregulation play a pivotal role in GC development, activating pathways that induce tumor progression. Understanding the intricate connection between depression and GC not only highlights the need for comprehensive psychological support but also unveils potential therapeutic targets. Addressing both the physical and psychological aspects of GC is essential for enhancing the overall well-being and outcomes of patients grappling with this complex disease.