Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2023; 29(6): 1026-1053
Published online Feb 14, 2023. doi: 10.3748/wjg.v29.i6.1026
Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study
Fares E.M Ali, Islam M. Ibrahim, Osama M Ghogar, Esraa K. Abd-alhameed, Hanan S. Althagafy, Emad H.M. Hassanein
Fares E.M Ali, Emad H.M. Hassanein, Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
Islam M. Ibrahim, Osama M Ghogar, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
Esraa K. Abd-alhameed, Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 12345, Egypt
Hanan S. Althagafy, Department of Biochemistry, Faculty of Science, University of Jeddah, Jeddah 12345, Saudi Arabia
Author contributions: Ali FE and Hassanein EH designed and critically wrote the manuscript; Ibrahim IM, Ghogar OM, and Abd-alhameed EK collected data, and drafted the manuscript; Althagafy HS contributed to manuscript revision and proof editing.
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fares E.M Ali, MSc, PhD, Lecturer, Research Scientist, Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Al-Azhar Street, Assiut 71524, Egypt. faresali@azhar.edu.eg
Received: November 19, 2022
Peer-review started: November 19, 2022
First decision: November 30, 2022
Revised: December 29, 2023
Accepted: January 29, 2023
Article in press: January 29, 2023
Published online: February 14, 2023
Processing time: 82 Days and 14 Hours
Core Tip

Core Tip: Ulcerative colitis (UC) is a common chronic type of inflammatory bowel disease that affects a significant number of populations. Needing to counteract the UC prevalence, attract scientists to study its pathological mechanism deeply. NLR family pyrin domain containing 3 (NLRP3) inflammasome has been observed to have a crucial role in the pathological features of UC. Targeting NLRP3 inflammasome signals with phytochemicals, plants, probiotics, and chemical agents could be promising candidates for fixing the UC problem.