©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2023; 29(5): 780-799
Published online Feb 7, 2023. doi: 10.3748/wjg.v29.i5.780
Published online Feb 7, 2023. doi: 10.3748/wjg.v29.i5.780
Transcriptome analysis creates a new era of precision medicine for managing recurrent hepatocellular carcinoma
Chun-Cheng Chiang, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, United States
Hsuan Yeh, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States
Siew-Na Lim, Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Siew-Na Lim, Wey-Ran Lin, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Wey-Ran Lin, Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Author contributions: Chiang CC and Yeh H contributed equally to this study, and both contributed to data collection and manuscript writing; Lim SN and Lin WR contributed to data collection and supervision.
Supported by Linkou Chang Gung Memorial Hospital , Taiwan, No. CORPG3L0271, No. CORPG3L0281, No. CMRPG3K2292, and No. CORPG3L0301; and Ministry of Science and Technology , No. MOST111-2314-B-182A-126 .
Conflict-of-interest statement: The authors report having no relevant conflicts of interest for this article.
Corresponding author: Wey-Ran Lin, MD, PhD, AGAF, Professor, Department of Gastro
Received: October 17, 2022
Peer-review started: October 17, 2022
First decision: November 15, 2022
Revised: November 23, 2022
Accepted: January 10, 2023
Article in press: January 10, 2023
Published online: February 7, 2023
Processing time: 111 Days and 22.5 Hours
Peer-review started: October 17, 2022
First decision: November 15, 2022
Revised: November 23, 2022
Accepted: January 10, 2023
Article in press: January 10, 2023
Published online: February 7, 2023
Processing time: 111 Days and 22.5 Hours
Core Tip
Core Tip: The high incidence of hepatocellular carcinoma (HCC) recurrence seriously threatens patient outcomes. This review detailed how various transcriptome profiling methods have contributed to our understanding of recurrent HCC with respect to the carcinogenicity of primary cancer cells, carcinogenic stimuli, and tumor microenvironments, which show great promise in improving the management of HCC.