Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2023; 29(36): 5240-5253
Published online Sep 28, 2023. doi: 10.3748/wjg.v29.i36.5240
Diagnostic value of methylated branched chain amino acid transaminase 1/IKAROS family zinc finger 1 for colorectal cancer
Ke Xu, Ai-Ru Yu, Shen-Bin Pan, Jie He
Ke Xu, Ai-Ru Yu, Shen-Bin Pan, Jie He, Clinical Medical College, Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Ke Xu, Ai-Ru Yu, Shen-Bin Pan, Department of Oncology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Jie He, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Author contributions: He J conceived and designed the study; Xu K, He J, Yu AR, and Pan SB performed the collection and assembly of data; Xu K, He J, and Yu AR performed study quality evaluation; Xu K and He J performed data analysis and interpretation; Xu K and Pan SB wrote the initial draft; All authors revised the manuscript, read and approved the final version of the manuscript.
Supported by Natural Science Foundation of Sichuan Province, No. 2023NSFSC0729; Wu Jieping Foundation Special Fund for Clinical Research, No. 320.6750.2022-19-100; Foundation of Key Clinical Specialty of Sichuan Province, No. 2022; School Foundation of Chengdu Medical College, No. CYZYB21-05.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie He, PhD, Doctor, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, No. 278 Baoguang Street, Chengdu 610500, Sichuan Province, China. 2325@cmc.edu.cn
Received: June 20, 2023
Peer-review started: June 20, 2023
First decision: August 26, 2023
Revised: September 1, 2023
Accepted: September 7, 2023
Article in press: September 7, 2023
Published online: September 28, 2023
Processing time: 92 Days and 5.4 Hours
Core Tip

Core Tip: DNA methylation, a commonly used target for detecting ctDNA in plasma, is often explored as diagnostic biomarker of cancer. Here, the present study systematically analyzed 12 studies including 6561 individuals to assess the diagnostic value of methylated branched chain amino acid transaminase 1 (BCAT1)/ IKAROS family zinc finger 1 (IKZF1) in plasma for colorectal cancer (CRC) through meta-analysis. The sensitivity and specificity of methylated BCAT1/IKZF1 in plasma for CRC diagnosis were 60% [95% confidence interval (CI) 53-67] and 92% (95%CI: 90-94), respectively. The detection of methylated BCAT1/IKZF1 has potential in CRC diagnosis, but the clinical application prospect needs to be explored.