©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2023; 29(30): 4701-4705
Published online Aug 14, 2023. doi: 10.3748/wjg.v29.i30.4701
Published online Aug 14, 2023. doi: 10.3748/wjg.v29.i30.4701
Pitfalls and promises of bile duct alternatives: There is plenty of room in the regenerative surgery
Ilya D Klabukov, Denis S Baranovskii, Department of Regenerative Medicine, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk 249036, Russia
Peter V Shegay, Andrey D Kaprin, Center for Innovative Radiological and Regenerative Technologies, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk 249036, Russia
Author contributions: Klabukov ID designed and performed research, and wrote the letter; Baranovskii DS analyzed data; Baranovskii DS, Shegay PV, and Kaprin AD revised the letter.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Ilya D Klabukov, MSc, PhD, Director, Department of Regenerative Medicine, National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 4 Koroleva Street, Obninsk 249036, Russia. ilya.klabukov@gmail.com
Received: May 31, 2023
Peer-review started: May 31, 2023
First decision: July 8, 2023
Revised: July 11, 2023
Accepted: July 25, 2023
Article in press: July 25, 2023
Published online: August 14, 2023
Processing time: 70 Days and 13.9 Hours
Peer-review started: May 31, 2023
First decision: July 8, 2023
Revised: July 11, 2023
Accepted: July 25, 2023
Article in press: July 25, 2023
Published online: August 14, 2023
Processing time: 70 Days and 13.9 Hours
Core Tip
Core Tip: Progress towards the development of clinically applicable bile duct substitutes can be achieved by applying an interdisciplinary approach. This approach should include the utilization of quantitative mathematical methods, principles of cross-tissue interactions for epithelial and submucosal tissues, as well as deep retrospective data analysis of the causes of success and failure in studies on the creation of bile duct substitutes.