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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2023; 29(26): 4120-4135
Published online Jul 14, 2023. doi: 10.3748/wjg.v29.i26.4120
Irritable bowel syndrome: Epidemiology, overlap disorders, pathophysiology and treatment
Kai-Yue Huang, Feng-Yun Wang, Mi Lv, Xiang-Xue Ma, Xu-Dong Tang, Lin Lv
Kai-Yue Huang, Feng-Yun Wang, Mi Lv, Xiang-Xue Ma, Xu-Dong Tang, Lin Lv, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China
Kai-Yue Huang, Feng-Yun Wang, Mi Lv, Xiang-Xue Ma, Xu-Dong Tang, Lin Lv, Institute of Digestive Diseases, Beijing Institute of Spleen and Stomach Disease of Traditional Chinese Medicine, Beijing 100091, China
Author contributions: Huang KY reviewed the literature and wrote the first draft of the paper; Wang FY contributed to searching the literature and edited it; Lv M and Ma XX contributed to revising the paper and wrote it; and Tang XD conceived the idea and edited it; Lv L contributed to writing the paper, completed Figures 3 and 4, and edited it extensively.
Supported by National Natural Science Foundation of China, No. 81873297; the Fundamental Research Funds for the Central Public Welfare Research Institutes, China, No. ZZ13-YQ-006; and Innovation Fund of Chinese Academy of Chinese Medical Sciences, China, No. CI2021A01003.
Conflict-of-interest statement: Dr. LV reports grants from National Natural Science Foundation of China, grants from The Fundamental Research Funds for the Central Public Welfare Research Institutes, China, and grants from Innovation Fund of Chinese Academy of Chinese Medical Sciences, outside the submitted work.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Lv, MD, Associate Chief Physician, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. lushangshitou@qq.com
Received: April 17, 2023
Peer-review started: April 17, 2023
First decision: May 12, 2023
Revised: May 19, 2023
Accepted: June 11, 2023
Article in press: June 11, 2023
Published online: July 14, 2023
Processing time: 84 Days and 0.6 Hours
Core Tip

Core Tip: Irritable bowel syndrome (IBS) is a physical and mental illness that is becoming more prevalent, and its impact on society is expanding. Understanding of IBS has changed since the release of the Rome IV diagnosis in 2016, and this paper reviews the literature from the past decade to find that research around the brain-gut axis, diet, and gut microbiota are at the forefront of IBS. Moreover, as the research on the physiopathology of IBS has advanced, the treatment model has become more refined, which has important clinical implications.