©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2023; 29(23): 3574-3594
Published online Jun 21, 2023. doi: 10.3748/wjg.v29.i23.3574
Published online Jun 21, 2023. doi: 10.3748/wjg.v29.i23.3574
Recent advances in treatment of nodal and gastrointestinal follicular lymphoma
Takuya Watanabe, Department of Internal Medicine and Gastroenterology, Watanabe Internal Medicine Aoyama Clinic, Niigata-city 9502002, Japan
Author contributions: Takuya Watanabe solely contributes to this manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Takuya Watanabe, MD, PhD, Director, Doctor, Department of Internal Medicine and Gastroenterology, Watanabe Internal Medicine Aoyama Clinic, 1-2-21 Aoyama, Nishi-ku, Niigata-city 9502002, Japan. nabetaku@dia-net.ne.jp
Received: April 13, 2023
Peer-review started: April 13, 2023
First decision: May 12, 2023
Revised: May 14, 2023
Accepted: May 22, 2023
Article in press: May 22, 2023
Published online: June 21, 2023
Processing time: 63 Days and 22.6 Hours
Peer-review started: April 13, 2023
First decision: May 12, 2023
Revised: May 14, 2023
Accepted: May 22, 2023
Article in press: May 22, 2023
Published online: June 21, 2023
Processing time: 63 Days and 22.6 Hours
Core Tip
Core Tip: Primary gastrointestinal follicular lymphomas (FLs) have been increasingly detected in Japan, especially due to recent advances in small bowel endoscopy and increased opportunities for endoscopic examination and endoscopic diagnosis. Previously, many gastrolienal FL cases are detected at an early stage, however, the number of advanced cases is expected to increase in the future. This editorial provides an overview of the recent therapeutic advances in nodal FL, including antibody-targeted therapy, bispecific antibody therapy, epigenetic mutations, and chimeric antigen receptor T-cell therapy, and we also discuss future possibilities for gastroenterologists to treat gastrointestinal FL, especially in advanced cases.