©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2023; 29(2): 332-342
Published online Jan 14, 2023. doi: 10.3748/wjg.v29.i2.332
Published online Jan 14, 2023. doi: 10.3748/wjg.v29.i2.332
Current opinion on the regulation of small intestinal magnesium absorption
Siriporn Chamniansawat, Division of Anatomy, Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, Muang 20131, Chonburi, Thailand
Nasisorn Suksridechacin, Biodiversity Research Centre, Thailand Institute of Scientific and Technological Research, Khlong Luang 12120, Pathum Thani, Thailand
Narongrit Thongon, Division of Physiology, Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, Muang 20131, Chonburi, Thailand
Author contributions: Chamniansawat S wrote the manuscript; Suksridechacin N wrote the manuscript; Thongon N wrote and edited the manuscript.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Corresponding author: Narongrit Thongon, PhD, Associate Professor, Division of Physiology, Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Road, Saensook, Muang 20131, Chonburi, Thailand.
Received: August 10, 2022
Peer-review started: August 10, 2022
First decision: October 20, 2022
Revised: October 25, 2022
Accepted: November 18, 2022
Article in press: November 18, 2022
Published online: January 14, 2023
Processing time: 145 Days and 3.5 Hours
Peer-review started: August 10, 2022
First decision: October 20, 2022
Revised: October 25, 2022
Accepted: November 18, 2022
Article in press: November 18, 2022
Published online: January 14, 2023
Processing time: 145 Days and 3.5 Hours
Core Tip
Core Tip: Small intestinal epithelium absorbs digested magnesium (Mg2+) through both transcellular active and paracellular passive mechanisms. Several regulatory factors of small intestinal Mg2+ uptake have been reported. Parathyroid hormone and fibroblast growth factor-23 directly inhibit transcellular Mg2+ absorption in the duodenum, jejunum, and ileum. The apical proton triggers acid-sensing ion-channel 1a and purinergic P2Y2 receptor activities, which stimulates mucosal bicarbonate secretion and induces MgCO3 precipitation to suppress absorption. Omeprazole suppresses Mg2+ absorption in the duodenum, jejunum, and ileum.