Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2023; 29(2): 241-256
Published online Jan 14, 2023. doi: 10.3748/wjg.v29.i2.241
Liver injury in COVID-19: Clinical features, potential mechanisms, risk factors and clinical treatments
Shu-Wu Zhao, Yi-Ming Li, Yi-Lin Li, Chen Su
Shu-Wu Zhao, Department of Anesthesiology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha 410013, Hunan Province, China
Yi-Ming Li, School of Basic Medical Science, Naval Medical University/Second Military University, Shanghai 200433, China
Yi-Lin Li, Department of Pathology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha 410013, Hunan Province, China
Chen Su, Department of Anesthesiology and Pain, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha 410013, Hunan Province, China
Author contributions: Zhao SW performed the majority of the writing, prepared the figures and tables; Li YM performed data accusation and writing; Li YL provided the input in writing the paper; Su C designed the outline and coordinated the writing of the paper.
Supported by the National Natural Science Foundation of China, No. 81901141; and the Scientific Research Project of Hunan Provincial Health Commission, No. 202204114480.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chen Su, MD, PhD, Assistant Professor, Doctor, Department of Anesthesiology and Pain, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, No. 283 Tongzipo Road, Yuelu District, Changsha 410013, Hunan Province, China. suchen@hnca.org.cn
Received: September 14, 2022
Peer-review started: September 14, 2022
First decision: October 19, 2022
Revised: November 11, 2022
Accepted: December 8, 2022
Article in press: December 8, 2022
Published online: January 14, 2023
Processing time: 114 Days and 0.2 Hours
Core Tip

Core Tip: A growing body of evidence suggests that patients with coronavirus disease 2019 (COVID-19) may experience varying degrees of liver injury. The characteristics and mechanisms of liver injury associated with COVID-19 are not fully understood. In this review, we summarized the clinical features, mechanisms, and management strategies of liver injury associated with COVID-19. Moreover, we collected all the information about high risk factors for liver injury from COVID-19, which is of significance and help for further study of liver damage related to severe acute respiratory syndrome coronavirus 2.