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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2022; 28(9): 933-947
Published online Mar 7, 2022. doi: 10.3748/wjg.v28.i9.933
Published online Mar 7, 2022. doi: 10.3748/wjg.v28.i9.933
Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients
Yonghoon Choi, Nayoung Kim, Ki Wook Kim, Hyeong Ho Jo, Jaehyung Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Department ofInternal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, South Korea
Nayoung Kim, Dong Ho Lee, Keun-Wook Lee, Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, South Korea
Hyeon Jeong Oh, Department of Pathology, Seoul National University Bundang Hospital, Seongnam 13620, South Korea
Hye Seung Lee, Department of Pathology, Seoul National University College of Medicine, Seoul 03080, South Korea
Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Hyung-Ho Kim, Department of Surgery, Seoul National University Bundang Hospital, Seongnam 13620, South Korea
Yun-Suhk Suh, Do Joong Park, Hyung-Ho Kim, Department of Surgery, Seoul National University College of Medicine, Seoul 03080, South Korea
Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Department of Radiology, Seoul National University Bundang Hospital, Seongnam 13620, South Korea
Kyoung Ho Lee, Young Hoon Kim, Department of Radiology, Seoul National University College of Medicine, Seoul 03080, South Korea
Author contributions: Choi Y analyzed the data, provided statistical support, and drafted the article; Kim N designed this study, collected the data, and edited the manuscript; Kim KW, Jo HH, Park J, Yoon H, Shin CM, Park YS, and Lee DH performed endoscopies for the diagnosis of gastric cancer and edited the text; Park YS, Ahn SH, Suh YS, and Park DJ performed surgeries for gastric cancer; Kim HH kindly provided surgical cohort information, advised on the design of this study and supervised the manuscript preparation; HJO and HSL performed the histologic diagnosis of gastric cancer; Kim JW, Kim JW and Lee KW administered chemotherapy to patients with advanced gastric cancer; and Chang W, Park JH, Lee YJ, Lee KH, and Kim YH performed the radiologic studies; all authors reviewed the final manuscript and provided comments.
Supported by National Research Foundation of Korea.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of SNUBH (IRB No. B-1902–523-107).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: To gain access to data, data requestors will need to sign a data access agreement. Proposals should be directed to the Ethics Committee of Seoul National University Bundang Hospital.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nayoung Kim, MD, PhD, Professor, Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam 13620, South Korea. nakim49@snu.ac.kr
Received: September 19, 2021
Peer-review started: September 19, 2021
First decision: November 7, 2021
Revised: November 8, 2021
Accepted: January 27, 2022
Article in press: January 27, 2022
Published online: March 7, 2022
Processing time: 165 Days and 3.6 Hours
Peer-review started: September 19, 2021
First decision: November 7, 2021
Revised: November 8, 2021
Accepted: January 27, 2022
Article in press: January 27, 2022
Published online: March 7, 2022
Processing time: 165 Days and 3.6 Hours
Core Tip
Core Tip: In the analyses of sex differences in gastric cancer (GC), the sex ratio between males and females was 2:1, but the incidence of diffuse-type cancer was higher in females until the age of 60 years. The average age of the female group was significantly younger, and cancer of the gastric body and diffuse-type histology were more common than those in the males. In addition, there was poor GC-specific survival rate in advanced-stage cancer in females, while comorbidities including cancers of other organs and respiratory diseases were more common in males.