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World J Gastroenterol. Feb 21, 2022; 28(7): 704-714
Published online Feb 21, 2022. doi: 10.3748/wjg.v28.i7.704
Will the collaboration of surgery and external radiotherapy open new avenues for hepatocellular carcinoma with portal vein thrombosis?
Jung Wan Choe, Hye Yoon Lee, Chai Hong Rim
Jung Wan Choe, Department ofInternal Medicine, Korea University Ansan Hospital, Ansan 15355, South Korea
Hye Yoon Lee, Department of Surgery, Korea University Ansan Hospital, Ansan 15355, South Korea
Chai Hong Rim, Department of Radiation Oncology, Korea University Ansan Hospital, Ansan 15355, South Korea
Author contributions: Rim CH contributed to conceptualization; Lee HY supervised the study; Choe JW and Rim CH wrote the original draft; Choe JW, Lee HY and Rim CH reviewed and edited the manuscript; All authors have read and agreed to the published version of the manuscript.
Supported by the National Research Fund of Korea, No. NRF-2021R1I1A2047475.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chai Hong Rim, MD, PhD, Assistant Professor, Department of Radiation Oncology, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan 15355, South Korea. crusion3@naver.com
Received: October 28, 2021
Peer-review started: October 28, 2021
First decision: December 12, 2021
Revised: December 17, 2021
Accepted: January 19, 2022
Article in press: January 19, 2022
Published online: February 21, 2022
Processing time: 112 Days and 5.3 Hours
Core Tip

Core Tip: The prognosis of hepatocellular carcinoma with portal vein involvement is poor, and there had been few available local modalities. However, with the development of radiotherapy techniques, the 1-year survival rate has been reported to be close to 45%-50% after palliation. Recently, a surgical approach has also been attempted showing encouraging results. Furthermore, the combination of surgery and radiation therapy showed effective results in studies including randomized studies. The combination of these two modalities are expected to increase efficacy of treating hepatocellular carcinoma with portal invasion.