Retrospective Study
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World J Gastroenterol. Aug 14, 2022; 28(30): 4133-4151
Published online Aug 14, 2022. doi: 10.3748/wjg.v28.i30.4133
Development and validation of a nomogram for predicting overall survival in cirrhotic patients with acute kidney injury
Yi-Peng Wan, An-Jiang Wang, Wang Zhang, Hang Zhang, Gen-Hua Peng, Xuan Zhu
Yi-Peng Wan, An-Jiang Wang, Wang Zhang, Hang Zhang, Gen-Hua Peng, Xuan Zhu, Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang 331706, Jiangxi Province, China
Xuan Zhu, Biomolecular Research Laboratory, Jiangxi Clinical Research Center for Gastroenterology, Nanchang 331706, Jiangxi Province, China
Author contributions: Wan YP, Wang AJ and Zhang W equally contributed to this work; Wang AJ and Zhu X contributed to the concept; Wan YP, Wang AJ and Zhang W designed this study; Wan YP performed the manuscript writing; Zhang W performed data analysis; Zhang H and Peng GH contributed to samples collection and data collection and validation; Zhu X were clinical experts and performed the manuscript revision; all authors read and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 81960120 and No. 82160115.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of The First Affiliated Hospital of Nanchang University (No. AF-SG-04-2.0).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent. For full disclosure, the details of the study are published on the home page of The First Affiliated Hospital of Nanchang University.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xuan Zhu, MD, Chief Doctor, Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang 331706, Jiangxi Province, China. waiyongtg@163.com
Received: February 7, 2022
Peer-review started: February 7, 2022
First decision: April 10, 2022
Revised: April 29, 2022
Accepted: July 22, 2022
Article in press: July 22, 2022
Published online: August 14, 2022
Processing time: 184 Days and 1.6 Hours
Core Tip

Core Tip: We investigated the potential risk factors for death in cirrhotic patients with acute kidney injury (AKI). A nomogram incorporating these risk factors was developed and evaluated by calculating the area under the receiver operating characteristic curve, constructing a calibration curve and performing decision curve analysis. Compared with Child-Turcotte-Pugh, the model for end-stage liver disease (MELD) and MELD-Na score, the nomogram has a better discriminative ability in predicting the overall survival of cirrhotic patients with AKI. Moreover, the nomogram was used to select patients with a high risk of death and assist clinicians in making clinical decisions.