Micelles as potential drug delivery systems for colorectal cancer treatment

doi:10.3748/wjg.v28.i25.2867

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2022; 28(25): 2867-2880
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2867

Micelles as potential drug delivery systems for colorectal cancer treatment

Zaynab Fatfat, Maamoun Fatfat, Hala Gali-Muhtasib

Zaynab Fatfat, Maamoun Fatfat, Hala Gali-Muhtasib, Department of Biology, American University of Beirut, Beirut 1107 2020, Lebanon

Hala Gali-Muhtasib, Center for Drug Discovery, American University of Beirut, Beirut 1107 2020, Lebanon

Author contributions: Fatfat Z and Fatfat M reviewed the literature and drafted the manuscript; Gali-Muhtasib H initiated the idea and revised the manuscript; All authors have read and approved the final manuscript.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Corresponding author: Hala Gali-Muhtasib, PhD, Professor, Department of Biology, and Center for Drug Discovery, American University of Beirut, Bliss street, Beirut 1107 2020, Lebanon. amro@aub.edu.lb

Received: January 15, 2022
Peer-review started: January 15, 2022
First decision: March 8, 2022
Revised: March 22, 2022
Accepted: May 27, 2022
Article in press: May 27, 2022
Published online: July 7, 2022
Processing time: 170 Days and 1.6 Hours

Core Tip

Core Tip: Polymeric micelle-based drug delivery has demonstrated promising therapeutic outcomes against colorectal cancer. These safe nanocarriers exhibit high encapsulation efficiency of chemotherapeutic drugs, improve their water solubility and enhance the stability of nucleic acid-based therapeutics. They also accumulate preferentially at colorectal cancer sites, increase the anticancer effect of the delivered therapeutics and reduce their side effects. Incorporating stimuli-responsive and tumor targeting moieties to their structure further enhances their targeting and therapeutic efficacy. This platform also provides an opportunity to simultaneously deliver different chemotherapeutic drugs or nucleic acid-based therapeutics with chemotherapeutic drugs to the colorectal tumor to achieve an enhanced anticancer response.