Autoimmune liver diseases in systemic rheumatic diseases

doi:10.3748/wjg.v28.i23.2527

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 21, 2022; 28(23): 2527-2545
Published online Jun 21, 2022. doi: 10.3748/wjg.v28.i23.2527

Autoimmune liver diseases in systemic rheumatic diseases

Chrong-Reen Wang, Hung-Wen Tsai

Chrong-Reen Wang, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan 70403, Taiwan

Hung-Wen Tsai, Department of Pathology, National Cheng Kung University Hospital, Tainan 70403, Taiwan

Author contributions: Wang CR designed the report; Wang CR and Tsai HW wrote the paper, collected the clinical data and analyzed the pathological specimens.

Conflict-of-interest statement: The authors declare having no real or potential conflicts of interest.

Corresponding author: Chrong-Reen Wang, MD, PhD, Full Professor, Department of Internal Medicine, National Cheng Kung University Hospital, No. 138 Sheng-Li Road, Tainan 70403, Taiwan. wangcr@mail.ncku.edu.tw

Received: December 10, 2021
Peer-review started: December 10, 2021
First decision: March 11, 2022
Revised: March 11, 2022
Accepted: May 13, 2022
Article in press: May 13, 2022
Published online: June 21, 2022
Processing time: 188 Days and 7.4 Hours

Core Tip

Core Tip: Liver dysfunction in systemic rheumatic diseases (SRDs) can be associated with prescribed drugs, viral hepatitis, alternative hepatic comorbidities and coexisting autoimmune liver diseases (AILDs), requiring an exclusion of secondary conditions before considering liver involvement. In AILDs, it is imperative to identify the overlapping SRDs at an early stage since such a coexistence may influence the disease course and prognosis. Commonly co-occurring SRDs in AILDs are Sjögren syndrome (SS), rheumatoid arthritis (RA) or systemic lupus erythematosus in autoimmune hepatitis, and SS, RA or systemic sclerosis in primary biliary cholangitis. Therapeutic options can be personalized to control coexisting conditions of liver autoimmunity and rheumatic manifestations in AILD-SRD overlap diseases.