Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2022; 28(22): 2482-2493
Published online Jun 14, 2022. doi: 10.3748/wjg.v28.i22.2482
Endoscopic classification and pathological features of primary intestinal lymphangiectasia
Ming-Ming Meng, Kui-Liang Liu, Xin-Ying Xue, Kun Hao, Jian Dong, Chun-Kai Yu, Hong Liu, Cang-Hai Wang, Hui Su, Wu Lin, Guo-Jun Jiang, Nan Wei, Ren-Gui Wang, Wen-Bin Shen, Jing Wu
Ming-Ming Meng, Kui-Liang Liu, Hong Liu, Cang-Hai Wang, Hui Su, Wu Lin, Guo-Jun Jiang, Nan Wei, Jing Wu, Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Xin-Ying Xue, Department of Respiratory and Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Kun Hao, Wen-Bin Shen, Departments of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Jian Dong, Ren-Gui Wang, Departments of Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Chun-Kai Yu, Departments of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Author contributions: Meng MM, Liu KL, Xue XY, Hao K, Dong J and Yu CK contributed equally to this work; Wu J, Meng MM and Liu KL were the gastroenterologists; Shen WB and Hao K were the lymphologist; Wang RG and Dong J performed the radiological diagnosis; Yu CK performed the pathological diagnosis; Meng MM and Xue XY designed the research study; Liu KL, Liu H, Wang CH, Su H, Lin W, Jiang GJ and Wei N performed the primary literature and data extraction; Meng MM, Xue XY analyzed the data and wrote the manuscript; Wu J, Shen WB and Wang RG were responsible for revising the manuscript for important intellectual content; and all authors read and approved the final version.
Supported by National Natural Science Foundation of China, No. 61876216; and Beijing Shijitan Hospital Foundation of Capital Medical University, No. 2019-LB12.
Institutional review board statement: The study was reviewed and approved by the Beijing Shijitan Hospital, Capital Medical University Institutional Review Board [Approval No. Sjtkyll-lx-2021(90)].
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at wujing36@163.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Wu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Street, Haidian District, Beijing 100038, China. wujing36@163.com
Received: November 2, 2021
Peer-review started: November 2, 2021
First decision: December 3, 2021
Revised: December 9, 2021
Accepted: April 28, 2022
Article in press: April 28, 2022
Published online: June 14, 2022
Processing time: 219 Days and 15.7 Hours
Core Tip

Core Tip: Primary intestinal lymphangiectasia (PIL) is a rare disorder that typically presents as protein-losing enteropathy, diarrhea, and limb edema. Here we analyzed the endoscopic presentation, post-lymphographic computed tomography findings, and pathological features of 123 patients with PIL. We classified PIL into four categories - nodular, granular, vesicle, and edema types, proposed the theory of nodular and vesicle types domestically through observation, and made breakthroughs in overcoming the issue of inaccurate diagnosis based on a few independent early-stage case reports.