Observational Study
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World J Gastroenterol. Jun 7, 2022; 28(21): 2361-2382
Published online Jun 7, 2022. doi: 10.3748/wjg.v28.i21.2361
Socioeconomics and attributable etiology of primary liver cancer, 1990-2019
Qing-Qing Xing, Jing-Mao Li, Xuan Dong, Dan-Yi Zeng, Zhi-Jian Chen, Xiao-Yun Lin, Jin-Shui Pan
Qing-Qing Xing, Xuan Dong, Dan-Yi Zeng, Zhi-Jian Chen, Xiao-Yun Lin, Jin-Shui Pan, Department of Hepatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Qing-Qing Xing, Xuan Dong, Dan-Yi Zeng, Zhi-Jian Chen, Xiao-Yun Lin, Jin-Shui Pan, Hepatology Research Institute, Fujian Medical University, Fuzhou 350005, Fujian Province, China
Jing-Mao Li, Department of Statistics, Xiamen University, Xiamen 361000, Fujian Province, China
Xuan Dong, Dan-Yi Zeng, School of Medicine, Xiamen University, Xiamen 361000, Fujian Province, China
Author contributions: Pan JS had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis; Pan JS was responsible for its conception and design; Xing QQ, Li JM, Dong X, Zeng DY, Chen ZJ, and Lin XY were responsible for the acquisition, analysis, or interpretation of data; Pan JS drafted the manuscript; Li JM and Dong X made critical revision of the manuscript for important intellectual content; Li JM and Pan JS conducted the data analysis; Xing QQ, Li JM, and Dong X contributed equally to the study.
Supported by the National Natural Science Foundation of China, No. 81871645 (to Pan JS).
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of First Affiliated Hospital of Fujian Medical University (MTCA, ECFAH of FMU[2015]084-1).
Informed consent statement: Not required.
Conflict-of-interest statement: All authors report no conflicts interests.
Data sharing statement: All data are available in the Supplementary material.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Shui Pan, MD, PhD, Chief Doctor, Professor, Department of Hepatology, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou 350005, Fujian Province, China. j.s.pan76@fjmu.edu.cn
Received: October 18, 2021
Peer-review started: October 18, 2021
First decision: December 27, 2021
Revised: January 7, 2022
Accepted: April 24, 2022
Article in press: April 24, 2022
Published online: June 7, 2022
Processing time: 227 Days and 5.4 Hours
Core Tip

Core Tip: Primary liver cancer (PLC) is a common cancer with high morbidity and mortality rates. PLC usually occurs as a preventable disease. An association was identified between socioeconomic development status and PLC burden. The leading attributable etiologies of PLC were hepatitis B for the middle and high middle Socio-demographic Index (SDI) locations, and hepatitis C and nonalcoholic steatohepatitis for the high SDI locations. Our findings are valuable to implement tailored prevention strategies for PLC.