Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2022; 28(10): 1024-1054
Published online Mar 14, 2022. doi: 10.3748/wjg.v28.i10.1024
Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis
Cristina M Hagen, Eva Roth, Theresia Reding Graf, François Verrey, Rolf Graf, Anurag Gupta, Giovanni Pellegrini, Nadège Poncet, Simone Mafalda Rodrigues Camargo
Cristina M Hagen, Eva Roth, François Verrey, Nadège Poncet, Simone Mafalda Rodrigues Camargo, Institute of Physiology, University of Zurich, Zurich 8057, ZH, Switzerland
Theresia Reding Graf, Rolf Graf, Anurag Gupta, Swiss Hepato-Pancreato-Biliary Center, Department of Visceral and Transplantation Surgery, Zurich University Hospital, Zurich 8091, ZH, Switzerland
Giovanni Pellegrini, Institute of Veterinary Pathology, University of Zurich, Zurich 8057, ZH, Switzerland
Author contributions: Camargo SM, Poncet N, and Hagen CM designed and coordinated the study; Hagen CM, Roth E, Reding T, Gupta A, Pellegrini G, and Camargo SM performed the experiments, acquired and analyzed data; Hagen CM, Reding T, Verrey F, Graf R, Poncet N, and Camargo SM interpreted the data; Hagen CM and Camargo SM wrote the manuscript; all authors approved of the final version of the article.
Supported by Swiss National Science Foundation, Grant No. 31_166430/1 (to Verrey F).
Institutional review board statement: The study was reviewed and approved by Professors François Verrey and Rolf Graf.
Institutional animal care and use committee statement: Animal experiments adhered to the internationally accepted principles for the care and use of laboratory animals (License ZH075/15, Zurich Cantonal Veterinary office, Switzerland).
Conflict-of-interest statement: The authors have nothing to disclose.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Simone Mafalda Rodrigues Camargo, PhD, Pharmacist, Senior Scientist, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, Zurich 8057, ZH, Switzerland. simone.camargo@physiol.uzh.ch
Received: August 22, 2021
Peer-review started: August 22, 2021
First decision: September 12, 2021
Revised: October 8, 2021
Accepted: January 27, 2022
Article in press: January 27, 2022
Published online: March 14, 2022
Processing time: 200 Days and 13.4 Hours
Core Tip

Core Tip: LAT1 (slc7a5) transports amino acids into cells and is an upstream regulator of metabolic signaling pathways. This transporter was shown to play an important role in highly proliferative cells during embryonic development and cancer, controlling protein synthesis and cell proliferation. In this study we provide evidence that LAT1 plays a role in the pancreatic acinar regeneration after acute pancreatitis. Additionally, knocking down LAT1 revealed a sex difference in the regenerative process, which may be supportive to understand gender differences in the clinical setting.