Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2021; 27(7): 576-591
Published online Feb 21, 2021. doi: 10.3748/wjg.v27.i7.576
Xiangbinfang granules enhance gastric antrum motility via intramuscular interstitial cells of Cajal in mice
Qi-Cheng Chen, Zhi Jiang, Jun-Hong Zhang, Li-Xing Cao, Zhi-Qiang Chen
Qi-Cheng Chen, Zhi Jiang, Li-Xing Cao, Zhi-Qiang Chen, The Research Team of TCM Applications of Perioperative, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
Jun-Hong Zhang, Department of Research Public Service Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
Author contributions: Chen QC, Cao LX and Chen ZQ designed the research study; Chen QC, Jiang Z and Zhang JH performed the research; Chen QC analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Supported by The Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine, No. YN10101902; and the National Regional Traditional Chinese Medicine (Specialist) Clinic Construction, No. (2018)205.
Institutional review board statement: The study was reviewed and approved by the Institutional Animal Care and Ethics Committee of Guangdong Provincial Hospital of Traditional Chinese Medicine (approval No. 2018003).
Institutional animal care and use committee statement: All animal procedures were conducted according to the Regulations for the Care and Use of Laboratory Animals in Guangzhou University of Chinese Medicine.
Conflict-of-interest statement: The authors declare that there is no conflict of interest in this study.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at wssq@gzucm.edu.cn.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Qiang Chen, MD, Professor, The Research Team of TCM Applications of Perioperative, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 111 Dade Road, Guangzhou 510120, Guangdong Province, China. wssq@gzucm.edu.cn
Received: October 27, 2020
Peer-review started: October 27, 2020
First decision: December 13, 2020
Revised: December 24, 2020
Accepted: January 13, 2021
Article in press: January 13, 2021
Published online: February 21, 2021
Processing time: 116 Days and 1.1 Hours
Core Tip

Core Tip: This study shows that intramuscular interstitial cells of Cajal (ICC-IM) play crucial roles in regulating the activity of gastric antral migrating motor complexes (MMC). This may be an important bridge between the vagus, enteric nervous system and motilin to regulate smooth muscle contraction. Through the muscarinic receptor pathway on ICC-IM, the Chinese medicine Xiangbinfang granules depolarize smooth muscle cells and initiates an action potential, changing the periodic motion of MMC into a phase III-like contraction pattern in the gastric antrum of mice.