Yura M, Takano K, Adachi K, Hara A, Hayashi K, Tajima Y, Kaneko Y, Ikoma Y, Fujisaki H, Hirata A, Hongo K, Yo K, Yoneyama K, Dehari R, Koyanagi K, Nakagawa M. Pancreaticoduodenectomy after neoadjuvant chemotherapy for gastric cancer invading the pancreatic head: A case report. World J Gastroenterol 2021; 27(6): 534-544 [PMID: 33642827 DOI: 10.3748/wjg.v27.i6.534]
Corresponding Author of This Article
Masahiro Yura, MD, Doctor, Surgeon, Department of Surgery, Hiratsuka City Hospital, 1-19-1, Mihamihara, Hiratsuka 2540065, Kanagawa, Japan. myura@ncc.go.jp
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Masahiro Yura, Kiminori Takano, Kiyohiko Adachi, Asuka Hara, Keita Hayashi, Yuki Tajima, Yasushi Kaneko, Yoichiro Ikoma, Hiroto Fujisaki, Akira Hirata, Kumiko Hongo, Kikuo Yo, Kimiyasu Yoneyama, Motohito Nakagawa, Department of Surgery, Hiratsuka City Hospital, Hiratsuka 2540065, Kanagawa, Japan
Reiko Dehari, Department of Surgical Pathology, Hiratsuka City Hospital, Hiratsuka 2540065, Kanagawa, Japan
Kazuo Koyanagi, Department of Gastroenterological Surgery, Tokai University School of Medicine, Isehara 259193, Kanagawa, Japan
Author contributions: Yura M and Takano K performed the surgery and wrote the paper; Koyanagi K and Nakagawa M reviewed the manuscript; Dehari R contributed to pathological diagnosis; All other authors equally contributed to medical treatment; All authors were responsible for the revision of the manuscript and final approval for submission.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
Conflict-of-interest statement: All authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Masahiro Yura, MD, Doctor, Surgeon, Department of Surgery, Hiratsuka City Hospital, 1-19-1, Mihamihara, Hiratsuka 2540065, Kanagawa, Japan. myura@ncc.go.jp
Received: December 4, 2020 Peer-review started: December 4, 2020 First decision: December 24, 2020 Revised: January 6, 2021 Accepted: January 26, 2021 Article in press: January 26, 2021 Published online: February 14, 2021 Processing time: 63 Days and 5.8 Hours
Core Tip
Core Tip: Because of the high surgical risk and poor prognosis, pancreaticoduodenectomy (PD) is rarely performed for gastric cancer. However, due to advances in surgery and improvements in perioperative management, PD may be considered for gastric cancer to improve long-term survival. We present the successful case of radical resection with PD after neoadjuvant chemotherapy combined with trastuzumab for human epidermal growth factor receptor 2-positive locally advanced gastric cancer invading the pancreatic head without postoperative severe complication. This case suggests that radical resection with PD after neoadjuvant chemotherapy combined with trastuzumab is an option for locally advanced human epidermal growth factor receptor 2-positive gastric cancer invading the pancreatic head in the absence of non-curative factors.
