Li YD, Liu BN, Zhao SH, Zhou YL, Bai L, Liu EQ. Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea. World J Gastroenterol 2021; 27(5): 391-403 [PMID: 33584071 DOI: 10.3748/wjg.v27.i5.391]
Corresponding Author of This Article
En-Qi Liu, PhD, Director, Professor, Laboratory Animal Center, Institute of Atherosclerotic Disease, Xi’an Jiaotong University, No. 76 Yanta West Road, Xi’an 710061, Shaanxi Province, China. liuenqi@mail.xjtu.edu.cn
Research Domain of This Article
Microbiology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yan-Dong Li, Si-Hai Zhao, Laboratory Animal Center, Xi’an Jiaotong University Health Science Center, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Bao-Ning Liu, Research Institute of Atherosclerotic Disease and Laboratory Animal Center, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Yong-Li Zhou, Department of Gastroenterology, The First Affiliated Hospital of Xi’an Medical University, Xi’an 710077, Shaanxi Province, China
Liang Bai, En-Qi Liu, Laboratory Animal Center, Institute of Atherosclerotic Disease, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: Li YD and Liu EQ designed the study; Li YD, Liu BN, Zhao SH, Zhou YL and Bai L performed the experiments; Liu EQ and Zhao SH provided reagents and materials; Li YD and Liu BN analyzed the data; Li YD, Liu BN and Liu EQ wrote the main manuscript text and prepared the figures; all authors reviewed the manuscript.
Institutional review board statement: The study was undertaken with the approval of the Medical Ethics Board of the First Affiliated Hospital of Xi’an Medical University.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at email address. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: En-Qi Liu, PhD, Director, Professor, Laboratory Animal Center, Institute of Atherosclerotic Disease, Xi’an Jiaotong University, No. 76 Yanta West Road, Xi’an 710061, Shaanxi Province, China. liuenqi@mail.xjtu.edu.cn
Received: October 12, 2020 Peer-review started: October 12, 2020 First decision: November 23, 2020 Revised: November 30, 2020 Accepted: December 17, 2020 Article in press: December 17, 2020 Published online: February 7, 2021 Processing time: 108 Days and 15.5 Hours
Core Tip
Core Tip: Post-cholecystectomy diarrhea (PCD) is difficult to treat. Approximately 12%-35.6% of post-cholecystectomy patients have varying degrees of chronic diarrhea. Little is known regarding the intestinal microbiota characteristics in PCD patients. High-throughput sequencing of the 16S rRNA gene was used to characterize the composition and diversity of the complex intestinal microbial community in PCD patients. The results indicates that decreased diversity and abundance of the microbial community in the PCD group may cause diarrhea. These findings demonstrate the association between PCD and the gut microbiota, especially regarding Prevotella and Bifidobacterium. Thus, this study provides new insights into potential therapeutics that could target the microbiota to attenuate PCD.
