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Lapaquette P, Bizeau JB, Acar N, Bringer MA. Reciprocal interactions between gut microbiota and autophagy. World J Gastroenterol 2021; 27(48): 8283-8301 [PMID: 35068870 DOI: 10.3748/wjg.v27.i48.8283]
World J Gastroenterol. Dec 28, 2021; 27(48): 8283-8301 Published online Dec 28, 2021. doi: 10.3748/wjg.v27.i48.8283
Reciprocal interactions between gut microbiota and autophagy
Pierre Lapaquette, Jean-Baptiste Bizeau, Niyazi Acar, Marie-Agnès Bringer
Pierre Lapaquette, UMR PAM A 02.102, University Bourgogne Franche-Comté, Agrosup Dijon, Dijon 21000, France
Jean-Baptiste Bizeau, Niyazi Acar, Marie-Agnès Bringer, Eye and Nutrition Research Group, Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Dijon 21000, France
Author contributions: Lapaquette P and Bringer MA wrote the paper; Bizeau JB and Acar N revised the manuscript.
Supported byAgence Nationale de la Recherche, No. ANR-11-LABX-0021-01; French “Investissements d’Avenir” program, project ISITE-BFC, No. ANR-15-IDEX-0003; Conseil Régional de Bourgogne, Franche-Comté, No. RECH-E1INV-000131-0-EarlEAT; Institut Carnot Qualiment, INPROBIAUS grant; and FEDER (European Funding for Regional Economic Development), EARLEAT, PO FEDER-FSE Bourgogne 2014-2020 BG 0027905 BG 0027810.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Corresponding author: Marie-Agnès Bringer, PhD, Academic Research, Eye and Nutrition Research Group, Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Centre INRAE, 17 rue Sully, Dijon 21000, France. marie-agnes.bringer@inrae.fr
Received: June 18, 2021 Peer-review started: June 18, 2021 First decision: August 19, 2021 Revised: September 9, 2021 Accepted: December 2, 2021 Article in press: December 7, 2021 Published online: December 28, 2021 Processing time: 188 Days and 20 Hours
Core Tip
Core Tip: We are now aware that maintaining a fine equilibrium between the host and its gut microbiota is a prerequisite to maintain host homeostasis and promote long-term health. Several host and microbial processes interact dynamically to respond to external stresses. Among these processes, host autophagy acts as a cytoprotective mechanism responsive to a wide range of stress conditions, including metabolic, immune, and microbial stimuli. Autophagy was initially described as a degradative process active upon nutrient starvation. However, this process fulfils a wide range of other functions that are essential to host homeostasis. We discuss herein reciprocal interactions of autophagy with the gut microbiota in health and disease conditions.
