Letter to the Editor
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2021; 27(40): 7000-7004
Published online Oct 28, 2021. doi: 10.3748/wjg.v27.i40.7000
Gastrointestinal and hepatic involvement during COVID-19 pandemic: A focus on pediatric population and possible future implications
Rossella Sica, Serena Pennoni, Laura Penta, Sara Riccioni, Giuseppe Di Cara, Alberto Verrotti
Rossella Sica, Serena Pennoni, Laura Penta, Sara Riccioni, Giuseppe Di Cara, Alberto Verrotti, Department of Pediatrics, University of Perugia, Perugia 06132, PG, Italy
Author contributions: Sica R drafted the manuscript; Sica R, Pennoni S, Penta L, Riccioni S, Di Cara G and Verrotti A edited and revised the manuscript; Verrotti A supervised and approved the final version of the manuscript; all authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alberto Verrotti, MD, PhD, Chief Doctor, Professor, Department of Pediatrics, University of Perugia, Piazza L Severi 1, Perugia 06132, PG, Italy. alberto.verrottidipianella@unipg.it
Received: August 5, 2021
Peer-review started: August 5, 2021
First decision: August 19, 2021
Revised: August 30, 2021
Accepted: September 15, 2021
Article in press: September 15, 2021
Published online: October 28, 2021
Processing time: 82 Days and 19.6 Hours
Core Tip

Core Tip: Gastrointestinal and hepatic symptoms are a common clinical feature of the coronavirus disease 2019 (COVID-19). Moreover, a novel syndrome known as multisystem inflammatory syndrome (MIS-C) associated with COVID-19 in children and adolescents has emerged. Among the most common presenting symptoms of MIS-C, we found gastrointestinal and hepatic involvement. As gastrointestinal and hepatic involvement might play a major role in the clinical spectrum and possible sequelae of this novel condition, physicians should not underestimate these clinical manifestations. Therefore, abdominal ultrasonography monitoring and long-term follow-up could be useful to evaluate this potential damage and the possible outcome of these patients.