Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2021; 27(25): 3851-3862
Published online Jul 7, 2021. doi: 10.3748/wjg.v27.i25.3851
Zinc oxide nanoparticles reduce the chemoresistance of gastric cancer by inhibiting autophagy
You-Han Miao, Li-Ping Mao, Xiao-Juan Cai, Xiao-Ying Mo, Qi-Qi Zhu, Fei-Tong Yang, Mei-Hua Wang
You-Han Miao, Li-Ping Mao, Xiao-Juan Cai, Xiao-Ying Mo, Qi-Qi Zhu, Fei-Tong Yang, Mei-Hua Wang, Department of Infectious Disease, Nantong Third People’s Hospital, Nantong 226006, Jiangsu Province, China
Author contributions: Miao YH and Mao LP contributed equally to this study; Miao YH and Mao LP performed the majority of experiments and analyzed the data; Cai XJ and Mo XY performed the molecular investigations; Zhu QQ, Yang FT, and Wang MH designed and coordinated the research; Miao YH wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Nantong Third People’s Hospital.
Institutional animal care and use committee statement: Animal care and method procedure were authorized by the Animal Ethics Committee of Nantong Third People’s Hospital.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mei-Hua Wang, PhD, Chief Physician, Department of Infectious Disease, Nantong Third People’s Hospital, No. 60 Qingnian Middle Road, Nantong 226006, Jiangsu Province, China. huatsbfyy3617@163.com
Received: December 27, 2020
Peer-review started: December 27, 2020
First decision: January 23, 2021
Revised: January 27, 2021
Accepted: March 15, 2021
Article in press: March 15, 2021
Published online: July 7, 2021
Processing time: 190 Days and 12.1 Hours
Core Tip

Core Tip: We show that zinc oxide nanoparticle (ZnO-NP) reduces the chemoresistance of gastric cancer (GC) cells by inhibiting autophagy. Our findings provide innovative insights into the scenario in which ZnO-NP mediates chemotherapy resistance in GC. ZnO-NP may serve as a potential therapeutic candidate for GC treatment.