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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2021; 27(1): 92-106
Published online Jan 7, 2021. doi: 10.3748/wjg.v27.i1.92
Published online Jan 7, 2021. doi: 10.3748/wjg.v27.i1.92
Valuable clinical indicators for identifying infantile-onset inflammatory bowel disease patients with monogenic diseases
Wen Su, Yi Yu, Xu Xu, Xin-Qiong Wang, Jie-Bin Huang, Chun-Di Xu, Yuan Xiao, Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
Author contributions: Su W and Yu Y contributed equally to this work; Su W and Yu Y were in charge of the data analysis and writing; Xu X and Wang XQ contributed to data collection; Huang JB contributed to literature search and figure preparation; Xu CD and Xiao Y contributed to study design and data interpretation, and they contributed equally to this work; all authors have read and approved the final manuscript.
Supported by Scientific Research Fund of Shanghai Municipal Health Commission , No. 201640368 ; National Natural Science Foundation of China , No. 81741103 ; and The Shanghai Plan for Women and Children's Health Service Capacity Construction (Enhancing the Service Capacity of Shanghai Women and Children Health Care Institutions).
Institutional review board statement: This study was approved by the ethics committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine.
Informed consent statement: All guardians of the enrolled pediatric patients who experienced the gene test signed an informed consent form.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan Xiao, MD, PhD, Associate Chief Physician, Doctor, Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, No. 197 Ruijin 2 Road, Shanghai 200025, China. yxiao.penicilinum@gmail.com
Received: October 16, 2020
Peer-review started: October 16, 2020
First decision: November 23, 2020
Revised: December 2, 2020
Accepted: December 11, 2020
Article in press: December 11, 2020
Published online: January 7, 2021
Processing time: 75 Days and 9 Hours
Peer-review started: October 16, 2020
First decision: November 23, 2020
Revised: December 2, 2020
Accepted: December 11, 2020
Article in press: December 11, 2020
Published online: January 7, 2021
Processing time: 75 Days and 9 Hours
Core Tip
Core Tip: It is very important to identify infantile-onset inflammatory bowel disease (IO-IBD) patients, especially those in whom the disease is caused by monogenic diseases, as early as possible because these patients have poor responses to traditional inflammatory bowel disease treatments. However, there are no simple and reliable laboratory indicators for early differential diagnosis. This is the first study focusing on the laboratory indicators that could be used to distinguish O-IBD patients from allergic enteritis patients and screening IO-IBD patients with monogenic diseases. We believe that these results may be valuable in the initial investigations and diagnosis of IO-IBD.