Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2020; 26(9): 973-983
Published online Mar 7, 2020. doi: 10.3748/wjg.v26.i9.973
Effect and safety of mark-guided vs standard peroral endoscopic myotomy: A retrospective case control study
De-Feng Li, Feng Xiong, Zhi-Chao Yu, Hai-Yang Zhang, Ting-Ting Liu, Yan-Hui Tian, Rui-Yue Shi, Ming-Guang Lai, Yang Song, Zheng-Lei Xu, Ding-Guo Zhang, Jun Yao, Li-Sheng Wang
De-Feng Li, Feng Xiong, Zhi-Chao Yu, Hai-Yang Zhang, Ting-Ting Liu, Yan-Hui Tian, Rui-Yue Shi, Ming-Guang Lai, Yang Song, Zheng-Lei Xu, Ding-Guo Zhang, Jun Yao, Li-Sheng Wang, Department of Gastroenterology, the Second Clinical Medicine College (Shenzhen People's Hospital) of Jinan University, Shenzhen 518020, Guangdong Province, China
Author contributions: Wang LS and Yao J were responsible for design of the study and reviewed the manuscript. Li DF and Xiong F drafted the manuscript. Li DF, Xiong F and Yu ZC abstracted data. Liu TT, Tian YH, Shi RY, Lai MG, Song Y, Xu ZL and Zhang DG performed the POEM. Yao J and Wang LS were responsible for revising manuscript. All authors have read and approved the final manuscript.
Supported by Natural Science Foundation of Guangdong Province, No. 2018A0303100024; Shenzhen Health Planning Commission, No. SZXJ2017030.
Institutional review board statement: The research was reviewed and approved by the Institutional review board of Shenzhen Municipal People’s Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Li-Sheng Wang, MD, Doctor, Department of Gastroenterology, the Second Clinical Medicine College (Shenzhen People's Hospital) of Jinan University, 1017 East Gate Road, Shenzhen 518020, Guangdong Province, China. wanglsszrmyy@163.com
Received: October 30, 2019
Peer-review started: October 30, 2019
First decision: December 12, 2019
Revised: January 9, 2020
Accepted: January 19, 2020
Article in press: January 19, 2020
Published online: March 7, 2020
Processing time: 128 Days and 7 Hours
Core Tip

Core tip: Mark-guided Peroral endoscopic myotomy (POEM) can create full and large separation through sufficient sub-mucosal injection, which can improve the operative filed, decrease the incidence of bleeding, perforation and intra-procedural mucosal injury, and enhance the clinical success. By mark-guided POEM, it was not necessary to repeatedly pull out the tunnel to check the direction, thus saving the procedural time. Moreover, mark-guided POEM required less use of proton pump inhibitors and showed a lower incidence of reflux symptoms after the procedure.