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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2020; 26(7): 725-739
Published online Feb 21, 2020. doi: 10.3748/wjg.v26.i7.725
Published online Feb 21, 2020. doi: 10.3748/wjg.v26.i7.725
Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery
Masatsugu Ishii, Masahiro Shinoda, Minoru Kitago, Yuta Abe, Hiroshi Yagi, Yuko Kitagawa, Department of Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan
Osamu Itano, Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, International University of Health and Welfare School of Medicine, Chiba 286-8686, Japan
Taizo Hibi, Department of Pediatric Surgery and Transplantation, Kumamoto University, Kumamoto 860-8556, Japan
Ayano Takeuchi, Department of Public Health, Keio University School of Medicine, Tokyo 160-8582, Japan
Hanako Tsujikawa, Tokiya Abe, Department of Pathology, Keio University School of Medicine, Tokyo 160-8582, Japan
Author contributions: All authors equally contributed to this paper.
Institutional review board statement: This study was approved by the ethics committee of Keio University Hospital (approval Nos. 20120443 and 20140389).
Informed consent statement: All patients involved in this study provided informed consent prior to their study inclusion.
Conflict-of-interest statement: All other authors have nothing to disclose.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Osamu Itano, MD, PhD, Professor, Surgeon, Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, International University of Health and Welfare School of Medicine, 4-3 Kozunomori, Narita, Chiba 286-8686, Japan. laplivertiger@gmail.com
Received: November 22, 2019
Peer-review started: November 22, 2019
First decision: December 7, 2019
Revised: January 12, 2020
Accepted: January 19, 2020
Article in press: January 19, 2020
Published online: February 21, 2020
Processing time: 90 Days and 17.1 Hours
Peer-review started: November 22, 2019
First decision: December 7, 2019
Revised: January 12, 2020
Accepted: January 19, 2020
Article in press: January 19, 2020
Published online: February 21, 2020
Processing time: 90 Days and 17.1 Hours
Core Tip
Core tip: In this study, we identified the pre-hepatectomy factor associated with both early postoperative liver failure and long-term postoperative liver function recovery. We found that preoperative type IV collagen 7S is a significant independent factor associated with both post-hepatectomy liver failure and postoperative long-term recovery of liver function. Our analysis revealed that the time required for the recovery of Child-Pugh scores and serum total bilirubin and total bilirubin levels was significantly shorter in patients with type IV collagen 7S ≤ 6 ng/mL than in patients with type IV collagen 7S > 6 ng/mL.