Yang J, Zhang YH, Li JW, Shi YY, Huang JY, Luo Y, Liu JB, Lu Q. Contrast-enhanced ultrasound in association with serum biomarkers for differentiating combined hepatocellular-cholangiocarcinoma from hepatocellular carcinoma and intrahepatic cholangiocarcinoma. World J Gastroenterol 2020; 26(46): 7325-7337 [PMID: 33362387 DOI: 10.3748/wjg.v26.i46.7325]
Corresponding Author of This Article
Qiang Lu, MD, Professor, Department of Medical Ultrasound, West China Hospital of Sichuan University, No. 37 Guoxue Xiang, Chengdu 610041, Sichuan Province, China. luqiang@scu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Case Control Study
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Yang J, Zhang YH, Li JW, Shi YY, Huang JY, Luo Y, Liu JB, Lu Q. Contrast-enhanced ultrasound in association with serum biomarkers for differentiating combined hepatocellular-cholangiocarcinoma from hepatocellular carcinoma and intrahepatic cholangiocarcinoma. World J Gastroenterol 2020; 26(46): 7325-7337 [PMID: 33362387 DOI: 10.3748/wjg.v26.i46.7325]
World J Gastroenterol. Dec 14, 2020; 26(46): 7325-7337 Published online Dec 14, 2020. doi: 10.3748/wjg.v26.i46.7325
Contrast-enhanced ultrasound in association with serum biomarkers for differentiating combined hepatocellular-cholangiocarcinoma from hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Jie Yang, Ya-han Zhang, Jia-Wu Li, Ying-Yu Shi, Jia-Yan Huang, Yan Luo, Ji-Bin Liu, Qiang Lu
Jie Yang, Jia-Wu Li, Ying-Yu Shi, Jia-Yan Huang, Yan Luo, Qiang Lu, Department of Medical Ultrasound, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Ya-han Zhang, Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Ji-Bin Liu, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, United States
Author contributions: Yang J and Lu Q designed the research; Yang J, Li JW, Shi YY, Luo Y and Lu Q performed the research; Zhang YH contributed to pathologic analysis studies; Yang J, Li JW, Shi YY, Huang JY and Lu Q collected the data. Yang J and Lu Q drafted the manuscript and reviewed the literature; Luo Y and Liu JB revised the manuscript; All authors approve the final version of the submitted manuscript and agree to ensure that any questions related to the work are appropriately resolved.
Supported byNational Natural Science Foundation of China, No. 81571697; and The Science and Technology Department of Sichuan Province, No. 2017SZ0003 and No. 2018FZ0044.
Institutional review board statement: This study was reviewed and approved by the review board of West China Hospital of Sichuan University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors have no financial relationships to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Corresponding author: Qiang Lu, MD, Professor, Department of Medical Ultrasound, West China Hospital of Sichuan University, No. 37 Guoxue Xiang, Chengdu 610041, Sichuan Province, China. luqiang@scu.edu.cn
Received: August 6, 2020 Peer-review started: August 6, 2020 First decision: October 18, 2020 Revised: October 31, 2020 Accepted: November 9, 2020 Article in press: November 9, 2020 Published online: December 14, 2020 Processing time: 129 Days and 18.9 Hours
Core Tip
Core Tip: The imaging features of combined hepatocellular-cholangiocarcinoma (CHC) are complicated due to its complex histopathological characteristics. In addition, biopsy may misguide the correct diagnosis of CHC due to sampling error or tissue insufficiency. This study investigated the diagnostic value of the contrast-enhanced ultrasound Liver Imaging Reporting and Data System classification in association with serological tumor markers in differentiating CHC from hepatocellular carcinoma and intrahepatic cholangiocarcinoma. The results showed that the combined diagnostic criteria had high specificity and negative predictive value but low sensitivity for the diagnosis of CHC. These findings could help radiologists and clinical investigators confidently exclude CHC lesions in the clinical setting.
