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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2020; 26(38): 5863-5873
Published online Oct 14, 2020. doi: 10.3748/wjg.v26.i38.5863
Published online Oct 14, 2020. doi: 10.3748/wjg.v26.i38.5863
Endoscopic ultrasound-measured muscular thickness of the lower esophageal sphincter and long-term prognosis after peroral endoscopic myotomy for achalasia
Ye Liao, Yu-Fan Wu, Jing-Jing Zhang, Bao-Zhen Zhang, Yi-Dan Wang, Sheng Wang, Xiang Liu, Si-Yu Sun, Jin-Tao Guo, Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Ting-Yue Xiao, Department of Science and Education, Shenyang Sixth People’s Hospital, Shenyang 110006, Liaoning Province, China
Author contributions: Liao Y and Guo JT were involved in the study conception and design; Guo JT, Wang S, Liu X, and Sun SY performed the research; Liao Y, Xiao TY, Wu YF, Zhang JJ, Zhang BZ, and Wang YD analyzed the data; Liao Y wrote the manuscript; Guo JT and Sun SY performed critical revision of the article for important intellectual content; all authors performed the final approval of the article.
Supported by National Natural Science Foundation of China , No. 81900601, Natural Science Foundation of Liaoning Province, No. 207541024; and Outstanding Scientific Fund of Shengjing Hospital , No. 201702 .
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board and the Ethics Committee of China Medical University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jin-Tao Guo, MD, PhD, Doctor, Professor, Research Fellow, Department of Gastroenterology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. guojt@sj-hospital.org
Received: June 4, 2020
Peer-review started: June 4, 2020
First decision: July 29, 2020
Revised: August 13, 2020
Accepted: September 10, 2020
Article in press: September 10, 2020
Published online: October 14, 2020
Processing time: 132 Days and 8.1 Hours
Peer-review started: June 4, 2020
First decision: July 29, 2020
Revised: August 13, 2020
Accepted: September 10, 2020
Article in press: September 10, 2020
Published online: October 14, 2020
Processing time: 132 Days and 8.1 Hours
Core Tip
Core Tip: This study investigated the clinical significance of lower esophageal muscularis propria (LEMP) thickness in achalasia patients. We retrospectively enrolled 82 patients who underwent peroral endoscopic myotomy (POEM) at our center. The results showed that endoscopic ultrasound-measured LEMP thickness may help diagnose achalasia and predict long-term prognosis after POEM. Patients with a thickened muscularis were typically older and had a longer disease course. Younger age and male gender were risk factors for recurrence. Achalasia was more likely to relapse after POEM in patients with a thin LEMP, although further validation is needed.