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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2020; 26(31): 4589-4606
Published online Aug 21, 2020. doi: 10.3748/wjg.v26.i31.4589
Published online Aug 21, 2020. doi: 10.3748/wjg.v26.i31.4589
Feasibility and efficacy evaluation of metallic biliary stents eluting gemcitabine and cisplatin for extrahepatic cholangiocarcinoma
Jing-Bo Xiao, Yang-Yang Hu, Xin-Jian Wan, Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, China
Jing-Bo Xiao, Hospitalist and Internal Medicine Inpatient Department, Shanghai Jiahui International Hospital, Shanghai 200233, China
Jun-Yong Weng, Gui-Long Deng, Department of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, China
Xin-Jian Wan, Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China
Author contributions: Wan XJ conceived the study; Xiao JB mainly carried out the experiments and wrote the manuscript; Weng JY, Hu YY assisted in performing experiments; Deng GL performed the surgical procedures; Wan XJ supervised the study and revised the article.
Supported by the National Natural Science Foundation of China , No. 81870452 and No. 81470904 ; Science and Technology Development Funds of Shanghai of China , No. 16411952400 .
Institutional review board statement: This study was approved by the Ethics Committee of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine.
Institutional animal care and use committee statement: All experimental procedures were approved by the Animal Care and Use Committee of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xin-Jian Wan, MD, Chief Doctor, Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 650 Xinsongjiang Road, Shanghai 201620, China. xinjian_wan_shsl@163.com
Received: June 3, 2020
Peer-review started: June 3, 2020
First decision: June 18, 2020
Revised: June 30, 2020
Accepted: July 30, 2020
Article in press: July 30, 2020
Published online: August 21, 2020
Processing time: 78 Days and 7.6 Hours
Peer-review started: June 3, 2020
First decision: June 18, 2020
Revised: June 30, 2020
Accepted: July 30, 2020
Article in press: July 30, 2020
Published online: August 21, 2020
Processing time: 78 Days and 7.6 Hours
Core Tip
Core tip: Drug-eluting stent is a new therapeutic concept for malignant biliary obstructions; however, studies on such stents have been limited, and all of them used single-drug-loaded nanofilms with a simple design and lacked complete serial in vitro and in vivo data. Our study was the first to apply dual chemotherapeutic medications to a drug-eluting stent with several improvements in the design compared to previous stents for the palliative therapy of extrahepatic cholangiocarcinoma, with a relatively complete preclinical evaluation. Our results indicate that this brand new stent can be a promising alternative to realize the dual functions of biliary drainage and local chemotherapy.