Ko SH, Jeon JI, Woo HA, Kim JM. Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway. World J Gastroenterol 2020; 26(3): 291-306 [PMID: 31988590 DOI: 10.3748/wjg.v26.i3.291]
Corresponding Author of This Article
Jung Mogg Kim, MD, PhD, Chairman, Director, Doctor, Professor, Department of Microbiology, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. jungmogg@hanyang.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Ko SH, Jeon JI, Woo HA, Kim JM. Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway. World J Gastroenterol 2020; 26(3): 291-306 [PMID: 31988590 DOI: 10.3748/wjg.v26.i3.291]
World J Gastroenterol. Jan 21, 2020; 26(3): 291-306 Published online Jan 21, 2020. doi: 10.3748/wjg.v26.i3.291
Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway
Su Hyuk Ko, Jong Ik Jeon, Hyun Ae Woo, Jung Mogg Kim
Su Hyuk Ko, Jong Ik Jeon, Jung Mogg Kim, Department of Microbiology and Department of Biomedical Science, Hanyang University College of Medicine and Graduate School of Biomedical Science and Engineering, Seoul 04763, South Korea
Hyun Ae Woo, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, South Korea
Author contributions: Ko SH performed the majority of experiments and analyzed the data; Jeon JI performed the molecular investigations; Woo HA participated equally in treatment of animals; Kim JM designed and coordinated the research; Ko SH and Kim JM wrote the manuscript; all authors approved the final version of the article.
Institutional animal care and use committee statement: All animal experiments were performed according to protocols approved by the Institutional Animal Care and Use Committee of Hanyang University and Ewha Womans University (IACUC No. 2013-0197A and IACUC No. 17-012).
Conflict-of-interest statement: None of the authors of this study has any conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Corresponding author: Jung Mogg Kim, MD, PhD, Chairman, Director, Doctor, Professor, Department of Microbiology, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. jungmogg@hanyang.ac.kr
Supported bythe Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology, South Korea, No. NRF-2018R1D1A1B07043350.
Received: October 28, 2019 Peer-review started: October 28, 2019 First decision: December 12, 2019 Revised: December 20, 2019 Accepted: January 11, 2020 Article in press: January 11, 2020 Published online: January 21, 2020 Processing time: 79 Days and 20.6 Hours
Core Tip
Core tip: Enterotoxigenic Bacteroides fragilis is associated with non-invasive diarrheal diseases, inflammatory bowel diseases, and colorectal cancers. Bacteroides fragilis enterotoxin (BFT) is responsible for these diseases. The present study demonstrated that signaling pathways involving reactive oxygen species-mediated ERK, p38 mitogen-activated protein kinases and Nrf2 activation in dendritic cells are required for heme oxygenase-1 (HO-1) induction during exposure to BFT. This signaling pathway is different from our previous report that BFT upregulates HO-1 in intestinal epithelial cells via a p38 mitogen-activated protein kinases- and NF-κB-dependent pathway. Therefore, this is the first report concerning the effects of BFT on the HO-1 induction pathway in dendritic cells.
