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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2020; 26(29): 4316-4326
Published online Aug 7, 2020. doi: 10.3748/wjg.v26.i29.4316
Published online Aug 7, 2020. doi: 10.3748/wjg.v26.i29.4316
Multivariate predictive model for asymptomatic spontaneous bacterial peritonitis in patients with liver cirrhosis
Bo Tu, Zhe Xu, Peng Zhao, Lei Shi, Xin Zhang, Guang Yang, En-Qiang Qin, Department of Infectious Disease, the Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100039, China
Yue-Ning Zhang, Center of Hepatology and Gastroenterology, Beijing Capital Medical University You’an Hospital, Beijing 100039, China
Jing-Feng Bi, Department of Clinical and Translational Medicine, the Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100039, China
Author contributions: Tu B designed and performed the research and wrote the paper; Zhang YN designed the research and supervised the report, and contributed equally as the first author; Bi JF and Xu Z performed the research and contributed to the analysis; Zhao P, Shi L, Zhang X and Yang G performed the research and provided clinical advice; Qin EQ designed the research and supervised the report.
Supported by the Digestive Medical Coordinated Development Center of Beijing Municipal Administration , No. XXZ0403 .
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Chinese People's Liberation Army General Hospital.
Informed consent statement: Informed written consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: En-Qiang Qin, MD, Chief Physician, Department of Infectious Disease, the Fifth Medical Center, Chinese People's Liberation Army General Hospital, 100 Western 4th Ring Middle Road, Beijing 100039, China. qeq2004@sina.com
Received: March 4, 2020
Peer-review started: March 4, 2020
First decision: April 12, 2020
Revised: June 2, 2020
Accepted: July 1, 2020
Article in press: July 1, 2020
Published online: August 7, 2020
Processing time: 155 Days and 21.2 Hours
Peer-review started: March 4, 2020
First decision: April 12, 2020
Revised: June 2, 2020
Accepted: July 1, 2020
Article in press: July 1, 2020
Published online: August 7, 2020
Processing time: 155 Days and 21.2 Hours
Core Tip
Core tip: This retrospective study established a multivariate diagnostic model for asymptomatic spontaneous bacterial peritonitis in liver cirrhosis patients with ascites. The multivariate predictive model constructed by multiple linear stepwise regression analysis was as follows: y (P) = 0.018 + 0.312 × MELD (model of end-stage liver disease) + 0.263 × PMN (ascites polymorphonuclear) + 0.184 × N (blood neutrophil percentage) + 0.233 × HCC (hepatocellular carcinoma) + 0.189 × renal dysfunction. The diagnostic efficacy of the model was 80.1%, sensitivity was 73.5% and specificity was 86.7%. This model may improve the early diagnosis of asymptomatic spontaneous bacterial peritonitis.