©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2020; 26(29): 4272-4287
Published online Aug 7, 2020. doi: 10.3748/wjg.v26.i29.4272
Published online Aug 7, 2020. doi: 10.3748/wjg.v26.i29.4272
Rno_circ_0005139 regulates apoptosis by targeting Wnt5a in rat anorectal malformations
Dan Liu, Yuan Qu, Zheng-Nong Cao, Hui-Min Jia, Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Liu D and Qu Y performed the experiments, and analyzed the results; Liu D drafted the manuscript; Cao ZN and Jia HM reviewed manuscript; Cao ZN supervised the manuscript; Jia HM revised the final manuscript; all authors revised and approved the final manuscript.
Supported by the National Natural Science Foundation of China , No. 81671503 .
Institutional review board statement: The study was reviewed and approved by Medical Research and New Technology Ethics Committee of Shengjing Hospital, affiliated with China Medical University.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals (licence No. 2016PS045K).
Conflict-of-interest statement: All other authors have nothing to disclose.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Corresponding author: Hui-Min Jia, PhD, Chief Doctor, Professor, Department of Pediatric Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. jiahm@sj-hospital.org
Received: February 7, 2020
Peer-review started: February 7, 2020
First decision: April 22, 2020
Revised: May 9, 2020
Accepted: May 26, 2020
Article in press: May 26, 2020
Published online: August 7, 2020
Processing time: 181 Days and 20.9 Hours
Peer-review started: February 7, 2020
First decision: April 22, 2020
Revised: May 9, 2020
Accepted: May 26, 2020
Article in press: May 26, 2020
Published online: August 7, 2020
Processing time: 181 Days and 20.9 Hours
Core Tip
Core tip: Rno_circ_0005139, miR-324-3p, and Wnt5a play regulatory roles in the pathogenesis of anorectal malformations (ARM). Rno_circ_0005139 is a potential biomarker or therapeutic target in the ARM. In general, this study provides an important basis for further studies on the diagnosis, treatment, and prevention of ARM.