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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2020; 26(28): 4018-4035
Published online Jul 28, 2020. doi: 10.3748/wjg.v26.i28.4018
Published online Jul 28, 2020. doi: 10.3748/wjg.v26.i28.4018
Clinical considerations in the management of non-alcoholic steatohepatitis cirrhosis pre- and post-transplant: A multi-system challenge
Justin A Steggerda, Krishnaraj Mahendraraj, Tsuyoshi Todo, Department of Surgery, Division of Transplantation, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States
Mazen Noureddin, Division of Digestive and Liver Diseases, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States
Author contributions: Steggerda JA and Noureddin M developed the concept and designed the research; Steggerda JA, Mahendraraj K, and Noureddin M participated in data acquisition; Steggerda JA, Mahendraraj K, Todo T, and Noureddin M participated in the drafting and editing of the manuscript; Steggerda JA and Noureddin M developed the tables and figures to accompany the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mazen Noureddin, MD, Doctor, Division of Digestive and Liver Diseases, Comprehensive Transplant Center, Cedars-Sinai Medical Center, 8900 Beverly Blvd, Suite 270, Los Angeles, CA 90048, United States. mazen.noureddin@cshs.org
Received: April 6, 2020
Peer-review started: April 6, 2020
First decision: April 26, 2020
Revised: May 7, 2020
Accepted: July 15, 2020
Article in press: July 15, 2020
Published online: July 28, 2020
Processing time: 112 Days and 23.9 Hours
Peer-review started: April 6, 2020
First decision: April 26, 2020
Revised: May 7, 2020
Accepted: July 15, 2020
Article in press: July 15, 2020
Published online: July 28, 2020
Processing time: 112 Days and 23.9 Hours
Core Tip
Core tip: Non-alcoholic steatohepatitis (NASH) is the most common chronic liver disease worldwide, and the fastest growing indication for liver transplantation (LT) in the United States. Patients with NASH represent a unique and challenging population due the high incidence of associated conditions (i.e. obesity, diabetes, and hypertension), which carry considerable risk of morbidity and mortality before and after LT due to cardiovascular disease and kidney disease. This article provides a comprehensive review of the conditions and challenges facing patients with NASH and provides recommendations for evaluation and management to optimize them before LT.