Saleh SA, Salama MM, Alhusseini MM, Mohamed GA. M2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals. World J Gastroenterol 2020; 26(21): 2864-2876 [PMID: 32550761 DOI: 10.3748/wjg.v26.i21.2864]
Corresponding Author of This Article
Ghada A Mohamed, MD, Lecturer, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Khalifa El-Maamon St., Abbassia, Cairo 11341, Egypt. ghadaabdelrahman@med.asu.edu.eg
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
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Saleh SA, Salama MM, Alhusseini MM, Mohamed GA. M2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals. World J Gastroenterol 2020; 26(21): 2864-2876 [PMID: 32550761 DOI: 10.3748/wjg.v26.i21.2864]
World J Gastroenterol. Jun 7, 2020; 26(21): 2864-2876 Published online Jun 7, 2020. doi: 10.3748/wjg.v26.i21.2864
M2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals
Shereen A Saleh, Mohamed M Salama, Marwan M Alhusseini, Ghada A Mohamed
Shereen A Saleh, Mohamed M Salama, Marwan M Alhusseini, Ghada A Mohamed, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo 11341, Egypt
Author contributions: Saleh SA designed the research; Alhusseini MM participated in the acquisition of data; Saleh SA, Salama MM, Alhusseini MM, Mohamed GA participated in the analysis and interpretation of the data; Saleh SA, Salama MM, Mohamed GA revised the article critically for important intellectual content; Mohamed GA wrote the paper.
Institutional review board statement: The study was reviewed and approved by the institutional review board of Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Informed consent statement: All study participants provided informed written consent prior to study enrolment.
Conflict-of-interest statement: All authors have nothing to disclose.
Data sharing statement: The statistical code and dataset are available from the corresponding author at ghadaabdelrahman@med.asu.edu.eg. The participants gave informed consent for the data sharing.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Corresponding author: Ghada A Mohamed, MD, Lecturer, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Khalifa El-Maamon St., Abbassia, Cairo 11341, Egypt. ghadaabdelrahman@med.asu.edu.eg
Received: January 4, 2020 Peer-review started: January 4, 2020 First decision: February 24, 2020 Revised: March 27, 2020 Accepted: May 28, 2020 Article in press: May 28, 2020 Published online: June 7, 2020 Processing time: 153 Days and 15.2 Hours
Core Tip
Core tip: For 12 wk, 80 chronic hepatitis C patients received a sofosbuvir/daclatasvir/± ribavirin treatment. All patients achieved sustained virologic response (SVR12). Serum Mac-2 binding protein glycosylation isomer (M2BPGi) levels, liver stiffness measurements, fibrosis-4 (FIB-4) and PAPAS index decreased significantly at SVR12. At baseline, M2BPGi was the best marker to distinguish patients with grade F4 fibrosis, patients with grade F2 from grade F0-1 fibrosis, patients with grade F3-4 from grade F0-2 fibrosis, and patients with grade F2-4 from grade F0-1 fibrosis. At SVR12, M2BPGi had the greatest AUCs for differentiating patients with grade F4 fibrosis, patients with grade F3 from grade F0-2 fibrosis, patients with grade F3-4 from grade F0-2 fibrosis, and patients with grade F2-4 from grade F0-1 fibrosis.
