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Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2020; 26(21): 2702-2714
Published online Jun 7, 2020. doi: 10.3748/wjg.v26.i21.2702
Role of regenerating islet-derived proteins in inflammatory bowel disease
Jodi-Ann Edwards, Nicholas Tan, Nadlie Toussaint, Peiqi Ou, Cathy Mueller, Albert Stanek, Vladimir Zinsou, Sean Roudnitsky, Michelle Sagal, Lisa Dresner, Alexander Schwartzman, Chongmin Huan
Jodi-Ann Edwards, Cathy Mueller, Albert Stanek, Sean Roudnitsky, Michelle Sagal, Lisa Dresner, Alexander Schwartzman, Department of Surgery, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, United States
Nicholas Tan, Nadlie Toussaint, Vladimir Zinsou, College of Medicine, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, United States
Peiqi Ou, MCB program, School of Graduate Studies, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, United States
Chongmin Huan, Department of Surgery and Cell Biology, State University of New York, Downstate Health Sciences University, Brooklyn, NY 11203, United States
Author contributions: Edwards JA, Tan N, Toussaint N and Huan C conceptualized, designed and drafted the manuscript; Edwards JA, Tan N, Toussaint N, Ou P, Mueller C, Stanek A, Zinsou V, Roudnitsky S, Sagal M and Huan C reviewed the literatures; Edwards JA, Toussaint N, Ou P, Mueller C, Stanek A, Dresner L, Schwartzman A and Huan C discussed and edited the manuscript; Huan C directed the study.
Conflict-of-interest statement: There is no conflict of interest associated with the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chongmin Huan, MD, PhD, Assistant Professor, Department of Surgery and Cell Biology, State University of New York, Downstate Health Sciences University, 450 Clarkson Ave, Brooklyn, NY 11203, United States. chongmin.huan@downstate.edu
Received: January 21, 2020
Peer-review started: January 21, 2020
First decision: March 15, 2020
Revised: March 26, 2020
Accepted: May 13, 2020
Article in press: May 13, 2020
Published online: June 7, 2020
Processing time: 136 Days and 19.5 Hours
Core Tip

Core tip: The clinical management of inflammatory bowel disease (IBD) remains a significant challenge due to the knowledge gap in its pathogenesis. In this review paper, we have discussed the literature regarding increased expressions of regenerating islet-derived proteins in IBD and proposed the potential clinical relevance of these proteins based on their known protective activities in the inflamed intestine. We therefore provide insight from a new perspective in order to advance IBD research and clinical management.