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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2020; 26(18): 2138-2154
Published online May 14, 2020. doi: 10.3748/wjg.v26.i18.2138
Published online May 14, 2020. doi: 10.3748/wjg.v26.i18.2138
Medical management of metabolic and cardiovascular complications after liver transplantation
Chiara Becchetti, Melisa Dirchwolf, Jean-François Dufour, Hepatology, Department of Visceral Surgery and Medicine, Inselspital, University Hospital Bern, Bern CH-3008, Switzerland
Chiara Becchetti, Melisa Dirchwolf, Jean-François Dufour, Department of Biomedical Research, University of Bern, Bern CH-3008, Switzerland
Melisa Dirchwolf, Hepatology, Hepatobiliary Surgery and Liver Transplant Unit, Hospital Privado de Rosario, Rosario S2000GAP, Santa Fe, Argentina
Vanessa Banz, Department of Visceral Surgery and Medicine, Inselspital, University Hospital Bern, Bern CH-3008, Switzerland
Vanessa Banz, Department of Clinical Research, University of Bern, Bern CH-3008, Switzerland
Author contributions: Becchetti C and Dirchwolf M contributed to this paper with conception, literature review and writing the manuscript; Banz V and Dufour JF participated in drafting, critical revision and editing; all the authors approved the final version of the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chiara Becchetti, MD, Research Associate, Hepatology, Department of Visceral Surgery and Medicine, Inselspital, University Hospital Bern, MEM F807 Murtenstrasse, 35, Bern CH-3008, Switzerland. chiara.becchetti@insel.ch
Received: January 29, 2020
Peer-review started: January 29, 2020
First decision: March 18, 2020
Revised: March 26, 2020
Accepted: April 29, 2020
Article in press: April 29, 2020
Published online: May 14, 2020
Processing time: 105 Days and 14.9 Hours
Peer-review started: January 29, 2020
First decision: March 18, 2020
Revised: March 26, 2020
Accepted: April 29, 2020
Article in press: April 29, 2020
Published online: May 14, 2020
Processing time: 105 Days and 14.9 Hours
Core Tip
Core tip: Recently there has been an increasing interest in extra hepatic-related complications after liver transplantation because they widely affect late morbidity and mortality. Metabolic and cardiovascular diseases and de novo neoplasia are considered to be among the main complications affecting long- and mid-term prognosis after liver transplantation. In this review, we will assess the prevalence of metabolic and cardiovascular complications after liver transplantation, their impact on post-transplant morbidity and mortality, and the optimal medical management currently available.