©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2020; 26(17): 2111-2118
Published online May 7, 2020. doi: 10.3748/wjg.v26.i17.2111
Published online May 7, 2020. doi: 10.3748/wjg.v26.i17.2111
Multiple carcinosarcomas of the esophagus with adeno-carcinomatous components: A case report
Hiroshi Okamoto, Takashi Kamei, Department of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan
Hiroshi Kikuchi, Department of Surgery, South Miyagi Medical Center, Miyagi 989-1253, Japan
Hiroshi Naganuma, Department of Pathology, Sendai City Hospital, Sendai 982-8502, Japan
Author contributions: Okamoto H is the main author of this article; Kikuchi H was the patient’s surgeon and prepared the manuscript; Naganuma H performed the pathological examination; Kamei T reviewed the manuscript; all authors have read and approved the final manuscript.
Informed consent statement: The patient provided informed written consent for all aspects of care described in this manuscript.
Conflict-of-interest statement: The authors have no conflicts to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Hiroshi Okamoto, MD, PhD, Assistant Professor, Doctor, Surgeon, Department of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University, 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. hi-ok-0531@med.tohoku.ac.jp
Received: February 29, 2020
Peer-review started: February 29, 2020
First decision: April 2, 2020
Revised: April 8, 2020
Accepted: April 28, 2020
Article in press: April 28, 2020
Published online: May 7, 2020
Processing time: 67 Days and 23.1 Hours
Peer-review started: February 29, 2020
First decision: April 2, 2020
Revised: April 8, 2020
Accepted: April 28, 2020
Article in press: April 28, 2020
Published online: May 7, 2020
Processing time: 67 Days and 23.1 Hours
Core Tip
Core tip: Epithelial-mesenchymal transition (EMT) has been associated with cancer invasion and metastasis as epithelial cells acquire the ability to migrate and invade; these observations have been related to the generation of a stem cell population within the neoplasm. We report here a resected case of multiple carcinosarcomas with adeno-carcinomatous components that may have developed secondary to EMT. Detailed elucidation of the relationship between the pathogenesis of carcinosarcoma and EMT are among the future challenges in this field.