Observational Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2020; 26(16): 1950-1961
Published online Apr 28, 2020. doi: 10.3748/wjg.v26.i16.1950
Effectiveness of very low-volume preparation for colonoscopy: A prospective, multicenter observational study
Marcello Maida, Emanuele Sinagra, Gaetano Cristian Morreale, Sandro Sferrazza, Giuseppe Scalisi, Dario Schillaci, Marco Ventimiglia, Fabio Salvatore Macaluso, Giovanni Vettori, Giuseppe Conoscenti, Concetta Di Bartolo, Serena Garufi, Domenico Catarella, Michele Manganaro, Clara Maria Virgilio, Salvatore Camilleri
Marcello Maida, Gaetano Cristian Morreale, Serena Garufi, Michele Manganaro, Salvatore Camilleri, Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Caltanissetta 93100, Italy
Emanuele Sinagra, Giuseppe Conoscenti, Gastroenterology and Endoscopy Unit, Istituto San Raffaele Giglio, Cefalù 90015, Italy
Sandro Sferrazza, Giovanni Vettori, Gastroenterology and Endoscopy Unit, Santa Chiara Hospital, Trento 38014, Italy
Giuseppe Scalisi, Concetta Di Bartolo, Domenico Catarella, Clara Maria Virgilio, Gastroenterology Unit, ARNAS Garibaldi, Catania 95100, Italy
Dario Schillaci, Gastroenterology Unit, Basarocco Hospital, Niscemi 93015, Caltanissetta, Italy
Marco Ventimiglia, Fabio Salvatore Macaluso, Department of Internal Medicine, Villa Sofia-Cervello Hospital, Palermo 90100, Italy
Author contributions: Maida M, Sinagra E and Macaluso FS are guarantors of integrity of entire study and contributed to the manuscript drafting and manuscript revision for important intellectual content; Maida M, Sinagra E, Morreale GC, Macaluso FS and Sferrazza S contributed to the manuscript editing; Ventimiglia M performed the statistical analysis; all authors contributed to data collection and had full control over preparation of manuscript.
Institutional review board statement: The study received Ethics Committee approval and was conducted in accordance with the principles of the Declaration of Helsinki and good clinical practice.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no proprietary, financial, professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of this manuscript.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at marcello.maida@hotmail.it. Participants gave informed consent for data sharing.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Marcello Maida, MD, Doctor, Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Via Giacomo Cusmano 1, Caltanissetta 93100, Italy. marcello.maida@hotmail.it
Received: January 10, 2020
Peer-review started: January 10, 2020
First decision: March 6, 2020
Revised: March 26, 2020
Accepted: April 21, 2020
Article in press: April 21, 2020
Published online: April 28, 2020
Processing time: 108 Days and 14.2 Hours
Core Tip

Core tip: The effectiveness of colonoscopy strictly depends on adequate bowel cleansing. Nevertheless, bowel preparation is not always well accepted and tolerated by all patients. Recently, a 1 L polyethylene glycol plus ascorbate solution has been introduced on the evidence of three phase-3 randomized controlled trials, but it had never been tested in the real-life. This prospective, multicenter, observational study performed on 1289 patients undergoing screening or diagnostic colonoscopy, confirmed the effectiveness and tolerability of very low-volume preparation for colonoscopy, also showing that it is an independent predictor of overall cleansing success, high-quality cleansing of the right colon and of tolerability.