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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2019; 25(45): 6619-6633
Published online Dec 7, 2019. doi: 10.3748/wjg.v25.i45.6619
Published online Dec 7, 2019. doi: 10.3748/wjg.v25.i45.6619
MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription
Liang Ge, Yu Wang, Quan-Hong Duan, Guo-Jing Liu, Department of Anal and Intestinal Surgery, Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China
Song-Shan Liu, Department of Surgery, Weifang Medical College, Weifang 261031, Shandong Province, China
Author contributions: Ge L and Liu GJ designed the research, analyzed the data, and wrote the paper; Wang Y, Liu SS, and Duan QH performed the research.
Institutional review board statement: This study was reviewed and approved by the Human Ethics Committee of Affiliated Hospital of Weifang Medical College.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The ARRIVE Guidelines have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Guo-Jing Liu, MD, Doctor, Department of Anus and Intestine Surgery, Affiliated Hospital of Weifang Medical University, No. 2428, Yuhe Road, Weifang 26103, Shandong Province, China. jinwi1237@163.com
Telephone: +86-13081698899 Fax: +86-536-3081628
Received: September 5, 2019
Peer-review started: September 5, 2019
First decision: October 14, 2019
Revised: October 29, 2019
Accepted: November 13, 2019
Article in press: November 13, 2019
Published online: December 7, 2019
Processing time: 92 Days and 7.2 Hours
Peer-review started: September 5, 2019
First decision: October 14, 2019
Revised: October 29, 2019
Accepted: November 13, 2019
Article in press: November 13, 2019
Published online: December 7, 2019
Processing time: 92 Days and 7.2 Hours
Core Tip
Core tip: The expression of microRNA-760 (miR-760) was decreased in gastric cancer (GC), which was related to poor clinical outcomes in GC patients. MiR-760 restrained cell proliferation and cell colony formation and induced cell apoptosis in GC cells. MiR-760 directly targets G-protein-coupled receptor kinase interacting protein-1 that is involved in tumorigenesis of GC.