Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 14, 2019; 25(42): 6299-6310
Published online Nov 14, 2019. doi: 10.3748/wjg.v25.i42.6299
Knockdown of lncRNAXLOC_001659 inhibits proliferation and invasion of esophageal squamous cell carcinoma cells
Feng-Zhi Li, Wen-Qiao Zang
Feng-Zhi Li, Wen-Qiao Zang, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Author contributions: Li FZ and Zang WQ designed the research; Li FZ performed the research; Li FZ and Zang WQ wrote the paper.
Supported by Excellent Youth Development Fund of Zhengzhou University, No. 1621328001.
Institutional review board statement: The study was approved by the ethics committee of Zhengzhou University.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Wen-Qiao Zang, PhD, Assistant Professor, College of Basic Medical Sciences, Zhengzhou University, No. 100, Kexue Avenue, Zhengzhou 450001, Henan Province, China. zangwenqiao@zzu.edu.cn
Telephone: +86-371-67781959
Received: July 21, 2019
Peer-review started: July 22, 2019
First decision: August 27, 2019
Revised: September 27, 2019
Accepted: November 1, 2019
Article in press: November 1, 2019
Published online: November 14, 2019
Processing time: 116 Days and 2.8 Hours
Core Tip

Core tip: Studies have shown that long non-coding RNAs (lncRNAs) play a key role in almost all key physiological and pathological processes, including different types of malignant tumors. Our previous lncRNA microarray results have shown that lncRNA XLOC_001659 is upregulated in esophageal squamous cell carcinoma (ESCC) tissues, with a fold change of 20.9 relative to normal esophageal tissues. But its effect and the molecular biological mechanisms on proliferation and invasion of ESCC cells remain unclear. Here we showed that knockdown of lncRNA XLOC_001659 inhibited proliferation and invasion of ESCC cells via regulation of miR-490-5p/PIK3CA, suggesting that it may play a role in ESCC tumorigenesis and progression.