©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2019; 25(35): 5300-5309
Published online Sep 21, 2019. doi: 10.3748/wjg.v25.i35.5300
Published online Sep 21, 2019. doi: 10.3748/wjg.v25.i35.5300
Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a
Qu Zhang, Jiao-Zhen Xu, Department of Radiotherapy Center, Hubei Cancer Hospital, Wuhan 430079, Hubei Province, China
Chi Zhang, Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China
Jian-Xin Ma, Department of Oncology, Lianyungang Municipal Oriental Hospital, Lianyungang 222042, Jiangsu Province, China
Hui Ren, Department of Chest Medicine, Hubei Cancer Hospital, Wuhan 430079, Hubei Province, China
Yu Sun, Department of Radiation Oncology, Wanbei Coal-Electricity Group General Hospital, Suzhou 234000, Anhui Province, China
Author contributions: Zhang Q performed the majority of experiments; Ma JX analyzed the data; Zhang C and Sun Y performed the molecular investigations; Xu JZ designed and coordinated the research; Ren H wrote the paper.
Supported by the National Natural Science Foundation of China , No. 81703028 ; and Hubei Cancer Hospital , No. 20162017B01 .
Institutional review board statement: This study was reviewed and approved by the Hubei Cancer Hospital Ethics Committee.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Corresponding author: Jiao-Zhen Xu, MSc, Attending Doctor, Department of Radiotherapy Center, Hubei Cancer Hospital, No. 116 Zhuodaoquan South Road, Hongshan District, Wuhan 430079, Hubei Province, China. fuposhuic51@163.com
Telephone: +86-27-190077000 Fax: +86-27-6003200
Received: May 16, 2019
Peer-review started: May 16, 2019
First decision: June 16, 2019
Revised: July 11, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: September 21, 2019
Processing time: 129 Days and 0.3 Hours
Peer-review started: May 16, 2019
First decision: June 16, 2019
Revised: July 11, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: September 21, 2019
Processing time: 129 Days and 0.3 Hours
Core Tip
Core tip: We found that circular RNA PIP5K1A (circPIP5K1A) was selectively upregulated in colon cancer. Through sponging miR-1273a, circPIP5K1A promoted cell survival and enhanced the invasive and migratory functions of colon cancer cells, eventually exacerbating malignant transformation.