Lu JD, Cao F, Ding YX, Wu YD, Guo YL, Li F. Timing, distribution, and microbiology of infectious complications after necrotizing pancreatitis. World J Gastroenterol 2019; 25(34): 5162-5173 [PMID: 31558864 DOI: 10.3748/wjg.v25.i34.5162]
Corresponding Author of This Article
Fei Li, MD, PhD, Chief Doctor, Professor, Surgeon, Department of General Surgery, Xuanwu Hospital of Capital Medical University, No. 45, Changchun Street, Xicheng District, Beijing 100053, China. feili36@ccmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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Lu JD, Cao F, Ding YX, Wu YD, Guo YL, Li F. Timing, distribution, and microbiology of infectious complications after necrotizing pancreatitis. World J Gastroenterol 2019; 25(34): 5162-5173 [PMID: 31558864 DOI: 10.3748/wjg.v25.i34.5162]
Jiong-Di Lu, Feng Cao, Yi-Xuan Ding, Yu-Lin Guo, Fei Li, Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Yu-Duo Wu, Department of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital University of Medical Sciences, Beijing 100029, China
Author contributions: Lu JD is the first author; Cao F and Li F designed and performed the research; Ding YX, Guo YL, and Wu YD contributed the analytical tools; Lu JD, Ding YX, and Guo YL analyzed the data; Lu JD wrote the manuscript; Cao F, Ding YX, and Li F revised the manuscript; and all authors read and approved the final manuscript.
Supported bythe Beijing Municipal Science & Technology Commission, No. Z171100001017077; the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support, No. XMLX201404.
Institutional review board statement: The study was reviewed and approved by the Xuanwu Hospital Institutional Review Board.
Informed consent statement: The data of our study cohort was obtained retrospectively from the Xuanwu Hospital Database of Capital Medical University. Hence informed consent statement is unnecessary.
Conflict-of-interest statement: None of the authors has a conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at feili36@ccmu.edu.cn.
Corresponding author: Fei Li, MD, PhD, Chief Doctor, Professor, Surgeon, Department of General Surgery, Xuanwu Hospital of Capital Medical University, No. 45, Changchun Street, Xicheng District, Beijing 100053, China. feili36@ccmu.edu.cn
Telephone: +86-10-83198731 Fax: +86-10-83198868
Received: June 26, 2019 Peer-review started: June 26, 2019 First decision: July 20, 2019 Revised: August 7, 2019 Accepted: August 19, 2019 Article in press: August 19, 2019 Published online: September 14, 2019 Processing time: 78 Days and 17.6 Hours
Core Tip
Core tip: In our study, Gram-negative bacteria were the main pathogens in necrotizing pancreatitis patients with infectious complications in our hospital. The most common Gram-negative bacteria were Escherichia coli and Pseudomonas aeruginosa. Additionally, the proportion of multidrug-resistant bacteria was relatively large, and caution should be used in the application of antibiotics. The extrapancreatic infection time was usually earlier than that of pancreatic infection. For patients with suspected infection, blood and respiratory pathogens should be cultured first. Third- or fourth-generation cephalosporins or carbapenems can be used as empirical drugs. Persistent organ failure, multidrug resistance, and multiple operations were risk factors for death.
