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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2019; 25(32): 4715-4726
Published online Aug 28, 2019. doi: 10.3748/wjg.v25.i32.4715
Published online Aug 28, 2019. doi: 10.3748/wjg.v25.i32.4715
Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis
Ran-Xu Zhu, Dong-Ye Yang, Wai-Kay Seto, Department of Gastroenterology and Hepatology, The University of Hong Kong–Shenzhen Hospital, Shenzhen 518053, Guangdong Province, China
Alfred Sze Lok Cheng, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
Henry Lik Yuen Chan, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Author contributions: Zhu RX and Cheng ASL conceived and designed the study; All authors provided material support; Zhu RX performed the experiments and collected the data; Zhu RX and Cheng ASL analyzed the data; Zhu RX wrote the manuscript; All authors reviewed the manuscript; Zhu RX and Cheng ASL revised the manuscript; Zhu RX and Chan HLY provided financial support; Cheng ASL and Chan HLY provided study supervision; All authors gave final approval of the version of the article to published.
Supported by the National Natural Science Foundation of China , No. 81702777 ; and Natural Science Foundation of Guangdong Province , No. 2015A030310053 .
Institutional review board statement: The study was reviewed and approved by the University of Hong Kong-Shenzhen Hospital Ethics Committee.
Conflict-of-interest statement: No potential conflicts of interest ware disclosed.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ran-Xu Zhu, MD, PhD, Doctor, Department of Gastroenterology and Hepatology, The University of Hong Kong–Shenzhen Hospital, No. 1 Haiyuan Road, Futian District, Shenzhen 518053, Guangdong Province, China. zhurx@hku-szh.org
Telephone: +86-755-86913333 Fax: +86-755-86913333
Received: March 28, 2019
Peer-review started: March 28, 2019
First decision: April 16, 2019
Revised: July 14, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: August 28, 2019
Processing time: 153 Days and 21.4 Hours
Peer-review started: March 28, 2019
First decision: April 16, 2019
Revised: July 14, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: August 28, 2019
Processing time: 153 Days and 21.4 Hours
Core Tip
Core tip: This study elucidated the function and mechanism of growth arrest-specific gene 2 (GAS2) in hepatocellular carcinoma (HCC) progression. By overexpression and knockdown approaches, we found that GAS2 inhibited the proliferation of HCC with wild-type p53. The effects of GAS2 on the cell cycle and apoptosis were investigated by flow cytometry, Annexin V apoptosis, and western blot assay, respectively. GAS2 suppressed HCC proliferation by deregulating the cell cycle and p53-dependent apoptosis pathway. Thus, GAS2 is expected to be a promising anti-oncogene and potential therapeutic target in HCC with wild-type p53.