©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2019; 25(32): 4673-4681
Published online Aug 28, 2019. doi: 10.3748/wjg.v25.i32.4673
Published online Aug 28, 2019. doi: 10.3748/wjg.v25.i32.4673
Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies
Qian-Qian Shao, Bang-Bo Zhao, Liang-Bo Dong, Hong-Tao Cao, Wei-Bin Wang, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China
Author contributions: Shao QQ, Dong LB and Zhao BB performed the literature review; Shao QQ and Cao HT wrote the manuscript; Wang WB was involved in reviewing and editing the manuscript.
Supported by the National Natural Science Foundation , No. 81773215 ; and the General Financial Grant from the China Postdoctoral Science Foundation , No. 2017M610813 .
Conflict-of-interest statement: All authors state that they have no competing interests.
Corresponding author: Wei-Bin Wang, MD, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Dongcheng District, Beijing 100730, China. wwb_xh@163.com
Telephone: +86-10- 69152600 Fax: +86-10-69152600
Received: March 2, 2019
Peer-review started: March 2, 2019
First decision: April 4, 2019
Revised: April 29, 2019
Accepted: May 3, 2019
Article in press: May 3, 2019
Published online: August 28, 2019
Processing time: 180 Days and 1.6 Hours
Peer-review started: March 2, 2019
First decision: April 4, 2019
Revised: April 29, 2019
Accepted: May 3, 2019
Article in press: May 3, 2019
Published online: August 28, 2019
Processing time: 180 Days and 1.6 Hours
Core Tip
Core tip: Surgical approach to gastrinoma differs in sporadic Zollinger-Ellison syndrome (ZES) and multiple endocrine neoplasia type 1-related ZES (MEN1/ZES), and the role of surgery in patients with ZES is controversial, especially in those with MEN1. The current article will present classical considerations as well as the controversies that exist today with regard to the surgical management of ZES. We also make a surgical treatment algorithm for ZES based on a thorough literature review and the evidence provided by the current papers. To our best knowledge, this is the first review focusing on the surgical treatment of ZES and giving a detail as well as through discussion on this topic.