©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2019; 25(31): 4360-4382
Published online Aug 21, 2019. doi: 10.3748/wjg.v25.i31.4360
Published online Aug 21, 2019. doi: 10.3748/wjg.v25.i31.4360
Treatment of hepatocellular carcinoma in patients with portal vein tumor thrombosis: Beyond the known frontiers
Lucia Cerrito, Brigida Eleonora Annicchiarico, Antonio Gasbarrini, Maurizio Pompili, Francesca Romana Ponziani, Division of Internal Medicine, Gastroenterology and Hepatology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy
Roberto Iezzi, Department of Bioimaging and Radiological Sciences, Institute of Radiology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy
Author contributions: Cerrito L, Pompili M and Ponziani FR were responsible for manuscript preparation, table design, reference collection and final editing; Annicchiarico BE, Iezzi R and Gasbarrini A contributed to this paper with drafting and critical revision and editing.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Corresponding author: Francesca Romana Ponziani, MD, PhD, Doctor, Division of Internal Medicine, Gastroenterology and Hepatology Unit, Fondazione Policlinico Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, Rome 00168, Italy. francesca.ponziani@gmail.com
Telephone: +39-347-1227242
Received: April 22, 2019
Peer-review started: April 22, 2019
First decision: June 10, 2019
Revised: June 24, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: August 21, 2019
Processing time: 122 Days and 12.5 Hours
Peer-review started: April 22, 2019
First decision: June 10, 2019
Revised: June 24, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: August 21, 2019
Processing time: 122 Days and 12.5 Hours
Core Tip
Core tip: Portal vein tumor thrombosis (PVTT) is a complex anatomical and clinical condition, including patients with different prognosis according to the degree of portal system involvement, tumor biological aggressiveness, complications caused by portal hypertension, patient’s clinical features and tolerance to antineoplastic treatments. For this reason, it is extremely important to focus on the most adequate treatment strategy for each group of PVTT patients.