©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2019; 25(29): 3972-3984
Published online Aug 7, 2019. doi: 10.3748/wjg.v25.i29.3972
Published online Aug 7, 2019. doi: 10.3748/wjg.v25.i29.3972
LncRNA MEG3 acts a biomarker and regulates cell functions by targeting ADAR1 in colorectal cancer
Wei Wang, Qing-Chang Li, College of Basic Medical Sciences, China medical University and Department of Pathology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Wei Wang, Teaching and Research Department of Pathology, Basic Medical College, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Ying Xie, Fei Chen, Department of Synopsis of The Golden Chamber, School of Basic Medical Sciences, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Xu Liu, Experiment and Training Center, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Li-Li Zhong, Department of Pathology, the First Clinical Medical College, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Hai-Qiang Wang, Department of Gastroenterology, the First Clinical Medical College, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Author contributions: Li QC designed the research; Wang W, Xie Y, Chen F, Liu X, Zhong LL and Wang HQ performed the research; Wang W and Xie Y analyzed the data; Wang W and Li QC wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board Committee of the First Affiliated Hospital of China Medical University.
Conflict-of-interest statement: We declare no conflicts of interest.
Corresponding author: Qing-Chang Li, PhD, Doctor, College of Basic Medical Sciences, China medical University and Department of Pathology, the First Affiliated Hospital of China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110001, Liaoning Province, China. sci18846185819@126.com
Telephone: +86-24-62255001
Received: April 28, 2019
Peer-review started: April 28, 2019
First decision: May 24, 2019
Revised: June 7, 2019
Accepted: June 25, 2019
Article in press: June 26, 2019
Published online: August 7, 2019
Processing time: 102 Days and 23.1 Hours
Peer-review started: April 28, 2019
First decision: May 24, 2019
Revised: June 7, 2019
Accepted: June 25, 2019
Article in press: June 26, 2019
Published online: August 7, 2019
Processing time: 102 Days and 23.1 Hours
Core Tip
Core tip: Long non-coding RNA (LncRNA) maternally expressed gene 3 (MEG3) is down-regulated in tissue, cell lines and serum. Colorectal cancer (CRC) patients with down-regulated serum MEG3 levels were had larger tumor sizes, and advanced clinical stages. LncRNA MEG3 functions as a diagnostic and prognostic marker in CRC. LncRNA MEG3 promotes cell proliferation and induced apoptosis in CRC. The effect of adenosine deaminase on RNA 1 may be the target of lncRNA MEG3 in CRC.