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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2019; 25(28): 3753-3763
Published online Jul 28, 2019. doi: 10.3748/wjg.v25.i28.3753
Published online Jul 28, 2019. doi: 10.3748/wjg.v25.i28.3753
Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis, treatment, and outcomes
Xiao-Qian Yang, Jin Ye, Yu-Hu Song, Division of Gastroenterology, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Xin Li, Qian Li, Department of Radiology, Union Hospital, Tongji Medical college, Huazhong University of Science and technology, Wuhan 430022, Hubei Province, China
Author contributions: Yang XQ and Song YH reviewed the literature; Song YH and Ye J established the design and conception of the paper; Li X and Li Q provided the radiological imaging data; all authors contributed to writing and revision of this review.
Supported by National Natural Science Foundation of China , No. 81570555 and No. 81770582 .
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yu-Hu Song, MD, PhD, Chief Doctor, Professor, Division of Gastroenterology, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, No 1277, Jiefang Avenue, Wuhan 430022, Hubei Province, China. yuhusong@163.com
Telephone: +86-27-85726678 Fax: +86-27-85726057
Received: March 17, 2019
Peer-review started: March 18, 2019
First decision: May 24, 2019
Revised: June 5, 2019
Accepted: June 25, 2019
Article in press: June 26, 2019
Published online: July 28, 2019
Processing time: 133 Days and 22.6 Hours
Peer-review started: March 18, 2019
First decision: May 24, 2019
Revised: June 5, 2019
Accepted: June 25, 2019
Article in press: June 26, 2019
Published online: July 28, 2019
Processing time: 133 Days and 22.6 Hours
Core Tip
Core tip: Hepatic sinusoidal obstruction syndrome (HSOS), also named hepatic veno-occlusive disease, is a hepatic vascular disease presenting with abdominal distension, painful hepatomegaly, jaundice, and weight gain. The intake of pyrrolizidine alkaloids (PAs) is one of the major etiologies of HSOS in China. Unfortunately, PAs-induced HSOS has not been extensively studied up to now. Here, we describe the pathogenesis, clinical profiles, diagnosis, treatment, and outcomes of patients with PAs-induced HSOS.